【摘要】：目的探討中性粒細(xì)胞計(jì)數(shù)與淋巴細(xì)胞計(jì)數(shù)比值(neutrophil to lymphocyte ratio,NLR)對(duì)胰腺癌患者預(yù)后的影響。方法回顧性分析2010年1月~2013年1月105例接受根治性手術(shù)的胰腺癌患者病歷資料。通過Log-rank單因素分析包括NLR在內(nèi)的臨床病理特征對(duì)術(shù)后1年生存率及中位生存時(shí)間的影響。并通過Cox風(fēng)險(xiǎn)模型將有意義的變量進(jìn)行多因素分析。結(jié)果依據(jù)患者術(shù)前血常規(guī)檢查,計(jì)算NLR,依據(jù)四分位點(diǎn),分為NLR2.1、2.1≤NLR2.8、2.8≤NLR4.3、NLR≥4.3 4個(gè)組,各組患者的術(shù)后中位生存時(shí)間分別為25、16、11、5個(gè)月。NLR2.1、2.1≤NLR2.8、2.8≤NLR4.3 3組1年生存率分別為84.7%、79.8%、36.2%,其中NLR≥4.3組患者1年生存率低于5%,差異有統(tǒng)計(jì)學(xué)意義(P均0.05)。多因素分析顯示,術(shù)前外周血NLR、腫瘤直徑、腫瘤分化程度、淋巴結(jié)轉(zhuǎn)移、脈管侵犯、腫瘤T分期、遠(yuǎn)處轉(zhuǎn)移是影響胰腺癌患者預(yù)后的獨(dú)立危險(xiǎn)因素(P均0.05)。結(jié)論術(shù)前外周血NLR可作為評(píng)價(jià)胰腺癌患者根治性手術(shù)后預(yù)后的指標(biāo)。
[Abstract]:Objective to investigate the effect of the ratio of neutrophil count and lymphocyte count (neutrophil to lymphocyte ratio,NLR) on the prognosis of pancreatic cancer patients. Methods the medical records of 105 patients with pancreatic cancer undergoing radical surgery from January 2010 to January 2013 were retrospectively analyzed. The effect of clinicopathological features, including NLR, on 1 year survival rate and median survival time was analyzed by Log-rank univariate analysis. And the Cox risk model will be meaningful variables for multivariate analysis. Results according to the preoperative blood routine examination, the NLR, was calculated and divided into 4 groups: NLR2.1,2.1 鈮，

本文編號(hào)：2318323