【摘要】：目的觀察胃蛋白酶原(PG)、癌胚抗原(CEA)、黏蛋白類(lèi)癌胚抗原(CA72-4)聯(lián)合檢測(cè)對(duì)胃癌的診斷和鑒別診斷效能。方法胃癌患者45例(A組)、胃潰瘍患者66例(B組)、萎縮性胃炎患者47例(C組)、慢性非萎縮性胃炎患者40例(D組),采用ELISA法檢測(cè)血清PGⅠ、PGⅡ,計(jì)算胃蛋白酶原比值(PGR,PGⅠ/PGⅡ);化學(xué)發(fā)光法檢測(cè)血清CEA、CA72-4。分析PGⅠ、PGⅡ、CEA、CA72-4單獨(dú)及聯(lián)合檢測(cè)診斷胃癌的敏感度和特異度。結(jié)果與D組比較,A組PGⅠ、PGR降低和CEA、CA72-4升高,B組PGⅠ、PGⅡ升高,C組PGⅠ、PGR降低和PGⅡ升高,P均0.05;與C組比較,A組PGⅡ降低和CEA、CA72-4升高,P均0.05。單獨(dú)檢測(cè)診斷胃癌的敏感度和特異度以PGR為最高,分別為62.5%、75.7%。聯(lián)合檢測(cè)診斷胃癌的敏感度和特異度以PGⅠ、PGR、CEA、CA72-4聯(lián)合為最高,分別為85.6和92.5%。結(jié)論 PG、CEA、CA72-4聯(lián)合檢測(cè)有助于胃癌的診斷及鑒別診斷,可作為胃癌篩查的指標(biāo)。
[Abstract]:Objective to investigate the diagnostic and differential diagnostic efficacy of pepsinogen (PG), carcinoembryonic antigen (CEA),) mucin carcinoembryonic antigen (CA72-4) in gastric cancer. Methods 45 patients with gastric cancer (group A), 66 patients with gastric ulcer (group B), 47 patients with atrophic gastritis (group C) and 40 patients with chronic non-atrophic gastritis (group D) were examined by ELISA method. The pepsinogen ratio (PGR,PG 鈪，

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