【摘要】：目的 DNA損傷是引起細(xì)胞老化的主要原因,細(xì)胞老化與腫瘤的發(fā)生發(fā)展密切相關(guān)。本研究旨在探討DNA損傷應(yīng)答和磷酸肌醇生物合成通路調(diào)控細(xì)胞老化及腫瘤發(fā)生的機(jī)制。方法以"腫瘤、DNA損傷、細(xì)胞老化和磷酸肌醇"等為關(guān)鍵詞,檢索PubMed、中國知網(wǎng)和萬方數(shù)據(jù)庫2000-01-2016-07的相關(guān)文獻(xiàn)。納入標(biāo)準(zhǔn):(1)涉及到DNA損傷與細(xì)胞老化和腫瘤之間的相關(guān)性;(2)與磷酸肌醇生物合成通路對細(xì)胞老化和腫瘤的調(diào)控有關(guān);(3)論述了細(xì)胞老化的相關(guān)表型及其產(chǎn)生機(jī)制。根據(jù)納入標(biāo)準(zhǔn),符合分析的文獻(xiàn)42篇。結(jié)果 DNA損傷主要通過p53/p21、p16INK4a/pRB以及GATA4通路調(diào)控細(xì)胞老化進(jìn)程。磷酸肌醇生物合成通路中的一些分子和蛋白激酶,如IP6、IP7和IP6K等也參與DNA損傷修復(fù)的調(diào)控,影響細(xì)胞老化及腫瘤發(fā)生。細(xì)胞老化既可以抑制腫瘤的發(fā)生也可以促進(jìn)腫瘤的發(fā)生。結(jié)論DNA損傷應(yīng)答和磷酸肌醇生物合成通路通過多種途徑調(diào)控細(xì)胞老化及腫瘤的發(fā)生,為腫瘤的防治提供了新靶點(diǎn)。
[Abstract]:Objective DNA damage is the main cause of cell aging, and cell aging is closely related to the occurrence and development of tumor. The aim of this study was to investigate the mechanisms of DNA damage response and inositol phosphate biosynthesis pathway regulating cell aging and tumorigenesis. Methods using "tumor, DNA damage, cell aging and inositol phosphate" as the key words, the relevant literatures of PubMed, and Wanfang database 2000-01-2016-07 were searched. The inclusion criteria were as follows: (1) the correlation between DNA damage and cell aging and tumor, (2) the regulation of inositol phosphate biosynthesis pathway on cell aging and tumor; (3) the phenotypes and mechanism of cell aging were discussed. According to the inclusion criteria, 42 articles were analyzed. Results DNA damage regulated the process of cell aging mainly through p53 / p21 p16INK4a / PRRB and GATA4 pathway. Some molecules and protein kinases in inositol phosphate biosynthesis pathway, such as IP6,IP7 and IP6K, are also involved in the regulation of DNA damage and repair, affecting cell aging and tumorigenesis. Cell aging can not only inhibit the occurrence of tumor, but also promote the occurrence of tumor. Conclusion DNA damage response and inositol phosphate biosynthesis pathway regulate cell aging and tumorigenesis through a variety of pathways, which provide a new target for the prevention and treatment of tumor.
【作者單位】： 哈爾濱醫(yī)科大學(xué)基礎(chǔ)醫(yī)學(xué)院醫(yī)學(xué)遺傳學(xué)研究室;哈爾濱醫(yī)科大學(xué)附屬第二醫(yī)院婦產(chǎn)科;
【基金】：國家自然科學(xué)基金(81272582)
【分類號】：R730.2

【相似文獻(xiàn)】

相關(guān)期刊論文 前1條

1 楊娟;陳杰;;DNA損傷應(yīng)答和卵巢癌的關(guān)系[J];中國婦幼保健;2014年17期

相關(guān)會議論文 前1條

1 謝晨;蔡秋嫻;蔣嵩山;;Let-7參與DNA損傷應(yīng)答的分子機(jī)理研究[A];中國遺傳學(xué)會第九次全國會員代表大會暨學(xué)術(shù)研討會論文摘要匯編（2009-2013）[C];2013年

，

本文編號：2298076