【摘要】：目的:觀察以硼替佐米或馬法蘭為主的化療方案,在初診有癥狀的MM或MP治療后復(fù)發(fā)難治性的多發(fā)性骨髓瘤(MM)患者維持治療中的療效。方法:對(duì)本院2008-2013年5年期間MM患者的臨床經(jīng)過及轉(zhuǎn)歸進(jìn)行了回顧性分析。19例初診有癥狀的MM(13例),復(fù)發(fā)難治性的MM患者(6例),以硼替佐米(bortezomib)+地塞米松(Dexamethasone)治療后進(jìn)行維持治療的VD組,17例(初診有癥狀的MM),接受馬法蘭+潑尼松治療后再進(jìn)行維持治療的為MP組,比較兩組的療效。結(jié)果:可評(píng)估的36例患者,中位隨訪時(shí)間16(1-64)個(gè)月,兩組患者半年復(fù)發(fā)率比較差異有統(tǒng)計(jì)學(xué)意義,VD組19例中半年無1例復(fù)發(fā),MP組17例中半年有5例復(fù)發(fā)(P0.05)。結(jié)論:VD作為MM患者維持治療的方案優(yōu)于MP方案,而且毒副作用小。
[Abstract]:Objective: to observe the efficacy of bortezomil or Mafang regimen in maintaining the treatment of relapsed multiple myeloma (MM) after initial symptomatic MM or MP treatment. Methods: the clinical course and outcome of MM patients from 2008 to 2013 in our hospital were retrospectively analyzed. There were 19 patients with symptomatic MM (13 cases) and 6 patients with relapsing refractory MM (6 cases). In the VD group treated with bortezomil (bortezomib) dexamethasone (Dexamethasone), 17 cases (the first symptomatic MM), treated with marfarin prednisone followed by maintenance therapy) were treated with MP. The curative effect of the two groups was compared. Results: the median follow-up time was 16 (1-64) months. There was a significant difference in the half year recurrence rate between the two groups. In the VD group, there was no recurrence in 19 cases in half a year. In MP group, 5 cases recurred in half a year (P0.05). Conclusion: VD is superior to MP regimen in maintenance therapy for MM patients, and has little side effect.
【作者單位】： 新疆克拉瑪依市中心醫(yī)院血液腫瘤科;中國(guó)醫(yī)學(xué)科學(xué)院血液病醫(yī)院;新疆烏魯木齊市疾病預(yù)防控制中心;
【分類號(hào)】：R733.3

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