【摘要】：目的 :分析小于35歲進展期乳腺癌患者的分子類型和轉(zhuǎn)移特征,并探討影響預(yù)后的因素。方法 :回顧性分析2011年1月至2016年1月在北京大學腫瘤醫(yī)院就診的發(fā)病年齡小于35歲的153例進展期乳腺癌患者,對其預(yù)后相關(guān)因素進行單因素和多因素分析。結(jié)果 :本組患者中位發(fā)病年齡為31.7歲,中位無病生存期為28.4個月。153例患者中,有直系腫瘤家族史24例(15.7%),初治Ⅳ期11例(7.2%);首發(fā)轉(zhuǎn)移部位以骨轉(zhuǎn)移最常見,為63例(41.2%)。隨訪至2016年4月,中位生存期為31.3個月,5年生存率為18.1%。多因素分析結(jié)果顯示,直系腫瘤家族史、雌激素受體陰性、孕激素受體陰性、腫瘤體積較大是獨立的不良預(yù)后因素(P值均0.05)。結(jié)論 :進展期年輕乳腺癌受年齡因素影響,預(yù)后明顯變差。腫瘤較大、激素受體陰性和腫瘤直系家族史是其獨立的不良預(yù)后因素。
[Abstract]:Objective: to analyze the molecular types and metastasis characteristics of advanced breast cancer patients aged less than 35 years, and to explore the prognostic factors. Methods: from January 2011 to January 2016, 153 patients with advanced breast cancer, aged less than 35 years, who were admitted to Peking University Cancer Hospital, were retrospectively analyzed. The prognostic factors were analyzed by univariate and multivariate analysis. Results: the median age of onset was 31.7 years, and the median disease-free survival time was 28.4 months. Among 153 patients, 24 (15.7%) had a family history of direct tumors, 11 (7.2%) had primary stage 鈪，

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