【摘要】：背景:在臨床工作中,同時具有外分泌及神經內分泌成分的胃癌并不少見,從單純腺癌中散在分布神經內分泌細胞(NECs)到神經內分泌癌中存在局灶腺癌成分均屬性該類腫瘤。神經內分泌成分在腫瘤中所占比例的不同對該腫瘤預后的影響,目前尚不清楚。方法:本課題回顧性分析了 2011年2月至2016年1月期間,在國家癌癥中心/中國醫(yī)學科學院腫瘤醫(yī)院進行胃癌D2根治術、病理診斷為具有腺癌及神經內分泌成分的胃癌的95例患者的臨床資料。我們分別采用10%,20%,30%,50%和70%作為神經內分泌所占的比例為界限來進行對照研究,分析患者的總生存期(OS)。使用Cox比例風險模型來分析影響預后的因素,通過Kaplan-Meier方法來繪制生存曲線,并使用Log-rank檢驗來比較生存曲線之間的差別。結果:95例患者的1年,2年,3年和4年總生存率分別為95.3%,83.8%,74.7%,70.5%。多因素分析結果顯示腫瘤直徑(≥4.7cm)(危險度[HR],2.246;95%可信區(qū)間[CI]為,1.721-2.785);pN3(HR,5.159;95%CI,1.032-19.342)與 OS 有著顯著相關性(P0.05)。而神經內分泌比例的差別與總生存率并無顯著相關性。結論:在具有腺癌及神經內分泌成分的胃癌中,神經內分泌所占比例的差異,并不影響患者的OS,只有腫瘤的直徑和轉移的淋巴結數目是獨立的預后影響因素。
[Abstract]:Background: gastric cancer with both exocrine and neuroendocrine components is not uncommon in clinical work. From (NECs) scattered in neuroendocrine cells in simple adenocarcinoma to focal adenocarcinoma in neuroendocrine carcinomas, the presence of this type of tumor is not uncommon. The effect of the proportion of neuroendocrine components on the prognosis of the tumor is unclear. Methods: from February 2011 to January 2016, D2 radical gastrectomy for gastric cancer was performed at the National Cancer Center / Cancer Hospital of the Chinese Academy of Medical Sciences. Clinical data of 95 patients with adenocarcinoma and neuroendocrine components diagnosed by pathology. We used 50% and 70%, respectively, as the limit of the proportion of neuroendocrine, to analyze the total survival time (OS).) of the patients. Cox proportional risk model was used to analyze the prognostic factors, Kaplan-Meier method was used to draw survival curve, and Log-rank test was used to compare the difference between survival curves. Results the overall survival rate of 95 patients with 1 year, 2 years, 3 years and 4 years was 95.3% and 83.8% respectively. Multivariate analysis showed that tumor diameter (鈮，

本文編號：2233560