【摘要】：目的評(píng)估晚期食管癌患者一線化療前基線營(yíng)養(yǎng)狀態(tài)對(duì)化療療效、不良反應(yīng)和患者生存期的影響。方法回顧性收集一線化療的56例不可手術(shù)的局部進(jìn)展期或轉(zhuǎn)移性食管癌患者的臨床資料及化療前營(yíng)養(yǎng)狀況資料,并分析其與患者化療療效、不良反應(yīng)及生存期的相關(guān)性。結(jié)果血紅蛋白(hemoglobin,Hb)的水平與患者3級(jí)以上血液學(xué)毒性明顯相關(guān),其中Hb130 g/L者較90~130 g/L者3級(jí)以上血液學(xué)毒性的發(fā)生率顯著降低(34.2%vs.72.2%,P=0.008),但兩者在3級(jí)以上非血液學(xué)毒性上并無(wú)差別(P0.05);多因素分析中,有無(wú)遠(yuǎn)處轉(zhuǎn)移和體重下降程度是患者的獨(dú)立預(yù)后因素,有遠(yuǎn)處轉(zhuǎn)移(P=0.005)、體重下降≥5%(P=0.002)與患者預(yù)后差相關(guān)。結(jié)論對(duì)于不可手術(shù)的局部進(jìn)展期或轉(zhuǎn)移性食管癌患者,化療前基線營(yíng)養(yǎng)狀態(tài)在預(yù)測(cè)化療不良反應(yīng)及評(píng)估患者預(yù)后方面有一定作用。
[Abstract]:Objective to evaluate the effects of baseline nutritional status on chemotherapy efficacy, adverse reactions and survival in patients with advanced esophageal cancer. Methods the clinical data and nutritional status of 56 patients with non-operative local advanced or metastatic esophageal carcinoma were collected retrospectively. The correlation between the clinical data and the curative effect, adverse reaction and survival time of the patients was analyzed. Results the level of hemoglobin (hemoglobin,Hb) was significantly correlated with the hematological toxicity of patients above grade 3. The incidence of hematological toxicity above grade 3 in Hb130 g / L group was significantly lower than that in 90 g / L group (34.2vs.72.2% P0. 008), but there was no difference in non-hematological toxicity between the two groups (P0.05). Distant metastasis and weight loss were independent prognostic factors. Distant metastasis (P0. 005) and weight loss 鈮，

本文編號(hào)：2228525