【摘要】：目的:探討治療前血清乳酸脫氫酶(LDH)與血清堿性磷酸酶(ALP)水平對鼻咽癌患者預(yù)后的影響。方法:收集2006-04-2008-10期間在我院初治的339例鼻咽癌患者的年齡、性別、T分期、N分期、臨床分期、放療方式、放療劑量、治療前血清LDH水平、治療前血清ALP水平等資料,應(yīng)用單因素和多因素分析的統(tǒng)計(jì)學(xué)方法分析其與鼻咽癌患者預(yù)后的相關(guān)性。結(jié)果:本組病例1、3、5年生存率分別為97.8%、85.0%、78.5%,單因素分析顯示年齡、臨床分期、治療前血清LDH與患者預(yù)后相關(guān)(P0.05)。多因素分析顯示年齡、臨床分期及治療前血清LDH水平是影響患者預(yù)后的獨(dú)立因素。結(jié)論:年齡大于50歲、Ⅲ+Ⅳ期及治療前血清LDH升高是鼻咽癌患者復(fù)發(fā)和死亡的獨(dú)立危險(xiǎn)因素。
[Abstract]:Objective: to investigate the effect of serum lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) levels on the prognosis of nasopharyngeal carcinoma (NPC) patients before treatment. Methods: the data of age, sex T staging, clinical stage, radiotherapy method, dose of radiotherapy, serum LDH level before treatment and serum ALP level before treatment were collected in 339 patients with nasopharyngeal carcinoma treated in our hospital from April to October 2006. Univariate and multivariate analysis were used to analyze its correlation with the prognosis of nasopharyngeal carcinoma (NPC) patients. Results: the 3- and 5-year survival rates of the patients were 97.80.85% and 78.5%, respectively. Univariate analysis showed that age, clinical stage and serum LDH were correlated with the prognosis of the patients (P0.05). Multivariate analysis showed that age, clinical stage and serum LDH level before treatment were independent factors for prognosis. Conclusion: the increase of serum LDH in patients over 50 years old and in stage 鈪，

本文編號：2220006