發(fā)布時(shí)間：2018-08-08 20:57

【摘要】：目的評(píng)估阿瑞匹坦/奧氮平聯(lián)合托烷司瓊和地塞米松方案在多日順鉑化療的女性患者中的有效性、安全性和費(fèi)用效益比。方法采用隨機(jī)對(duì)照研究方法,將87例女性腫瘤患者隨機(jī)分為阿瑞匹坦組(44例)和奧氮平組(43例)。阿瑞匹坦組止吐方案:阿瑞匹坦、托烷司瓊和地塞米松;對(duì)照組方案:奧氮平、托烷司瓊和地塞米松。結(jié)果 44例阿瑞匹坦組患者中,29例患者(65.9%)延遲期嘔吐達(dá)到完全緩解,43例患奧氮平組患者中,30例(69.8%)延遲期嘔吐達(dá)到完全緩解,兩組比較差異無統(tǒng)計(jì)學(xué)意義(P=0.690)。阿瑞匹坦組呃逆發(fā)生率更高(P=0.023),其余不良反應(yīng)兩組差異無統(tǒng)計(jì)學(xué)意義;而奧氮平導(dǎo)致的嗜睡作用更明顯(P=0.006)。血液學(xué)毒性方面兩組之間差異無統(tǒng)計(jì)學(xué)意義。每周期阿瑞匹坦組的費(fèi)用明顯高于奧氮平組(P0.01)。結(jié)論奧氮平聯(lián)合托烷司瓊和地塞米松用于女性肺癌和乳腺癌患者多日化療所致的延遲性惡心嘔吐安全性和有效性與阿瑞匹坦聯(lián)合托烷司瓊和地塞米松相似,但更具有費(fèi)用效益比優(yōu)勢(shì)。
[Abstract]:Objective to evaluate the efficacy, safety and cost-effectiveness of the combination of tropisetron and dexamethasone in multiday cisplatin chemotherapy in women. Methods 87 female patients with tumor were randomly divided into two groups: Aripitan group (n = 44) and olanzapine group (n = 43). The control group: olanzapine, tropisetron and dexamethasone. Results 29 (65.9%) patients (65.9%) with delayed vomiting achieved complete remission in 44 patients (65.9%). 30 (69.8%) of 43 patients with olanzapine had complete remission of delayed vomiting. There was no significant difference between the two groups (P0. 690). The incidence of hiccup in group A was higher than that in group A (P0. 023), but there was no significant difference in other adverse reactions between the two groups, while olanzapine had a more obvious effect on lethargy (P0. 006). There was no significant difference in hematological toxicity between the two groups. The cost per cycle of Arepitan group was significantly higher than that of olanzapine group (P0.01). Conclusion the safety and efficacy of olanzapine combined with tropisetron and dexamethasone in the treatment of delayed nausea and vomiting induced by multiple days chemotherapy in female patients with lung cancer and breast cancer are similar to those of aripitan combined with tropisetron and dexamethasone. But it has the advantage of cost-benefit ratio.
【作者單位】： 湖北省腫瘤醫(yī)院胸部腫瘤內(nèi)科;荊州市第三人民醫(yī)院腫瘤科;
【分類號(hào)】：R734.2;R737.9

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