【摘要】：探討胃早癌患者血清胃蛋白酶原(PG)水平及內(nèi)鏡治療前后的變化和意義。185例行內(nèi)鏡下黏膜切除術(shù)(EMR)或內(nèi)鏡下黏膜剝離術(shù)(ESD)的患者以及同時(shí)期胃鏡檢查陰性者90例、非萎縮性胃炎患者178例、萎縮性胃炎患者67例、胃潰瘍患者46例進(jìn)入到本研究。結(jié)果顯示,與其他各組相比,早癌內(nèi)鏡治療組患者血清PGⅠ和PGR(PGⅠ和PGⅡ的比值)顯著降低。早癌內(nèi)鏡治療組患者術(shù)后30天和90天的PGⅠ和PGR數(shù)值顯著升高、PGⅡ數(shù)值顯著降低。早癌內(nèi)鏡治療組患者按照男女性別分組計(jì)算得出的術(shù)前、術(shù)后30天、術(shù)后90天PGⅠ、PGⅡ、PGR的數(shù)值,兩組間各數(shù)值均無統(tǒng)計(jì)學(xué)差異(P0.05)。因此,PGⅠ和PGR可以用作胃早癌人群的篩查。胃早癌內(nèi)鏡治療術(shù)后PG和PGR的數(shù)值隨訪可在預(yù)防監(jiān)測胃癌有無復(fù)發(fā)上發(fā)揮作用,并可間接評(píng)價(jià)EMR和ESD內(nèi)鏡下治療的有效性。PG和PGR作為胃早癌人群的篩查以及術(shù)后預(yù)防和監(jiān)測指標(biāo),并不受性別影響。
[Abstract]:To investigate the changes and significance of serum pepsinogen (PG) level in patients with early gastric cancer and the changes before and after endoscopic treatment. 185 patients underwent endoscopic mucosal resection (EMR) or endoscopic mucosal dissection (ESD) and 90 patients with negative gastroscopy at the same time. 178 patients with non-atrophic gastritis, 67 patients with atrophic gastritis and 46 patients with gastric ulcer entered the study. The results showed that compared with other groups, the ratio of PG 鈪，

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