【摘要】：目的:研究乳腺癌患者術后發(fā)生下肢深靜脈血栓(deep venous thrombosis,DVT)的危險因素,分析血栓風險評估模型的臨床價值。方法:回顧性分析2013年1月至2016年6月天津醫(yī)科大學腫瘤醫(yī)院703例術后發(fā)生血栓的患者為血栓組,通過系統(tǒng)抽樣法選取對照組706例,分析乳腺癌患者術后發(fā)生下肢DVT的危險因素,并比較Khorana及Caprini血栓風險評估模型的預測價值。結果:比較血栓組與對照組的年齡、BMI≥30 kg/m~2、手術切除活檢確診、接受新輔助化療、手術時間2 h、治療前脂蛋白a(Lpa)475.5 mg/L、血漿蛋白C(PC)102.5%、血漿凝血因子Ⅷ(FⅧ)129.8%及D-二聚體(D-D)289.99 ng/m L,差異具有統(tǒng)計學意義(P0.05)。兩組患者的Khorana風險評估模型進行比較,差異無統(tǒng)計學意義(P=0.207);兩組患者的Caprini風險評估模型進行比較,差異具有統(tǒng)計學意義(P0.001)。結論:年齡、BMI≥30 kg/m~2、手術切除活檢確診、接受新輔助化療、手術時間2 h、治療前Lpa475.5 mg/L、PC102.5%、FⅧ129.8%及D-D289.99 ng/m L是乳腺癌術后發(fā)生下肢DVT的獨立危險因素,Caprini評估模型可能導致乳腺癌患者血栓風險評估偏高,應進一步探究更加適合乳腺癌患者血栓的風險評估模型。
[Abstract]:Objective: to study the risk factors of (deep venous thromboembolism (DVT) in patients with breast cancer after operation, and to analyze the clinical value of thrombus risk assessment model. Methods: from January 2013 to June 2016, 703 patients with postoperative thrombus in Tianjin Medical University Oncology Hospital were analyzed retrospectively. 706 patients in the control group were selected by systematic sampling. To analyze the risk factors of lower extremity DVT in breast cancer patients, and to compare the predictive value of Khorana and Caprini thrombus risk assessment models. Results: the age and BMI of thrombus group and control group were more than 30 kg / m ~ (-2), confirmed by surgical resection and biopsy, and accepted neoadjuvant chemotherapy. After 2 hours of operation, lipoprotein a (Lpa) 475.5 mg / L, plasma protein C (PC) 102.5, plasma coagulation factor 鈪，

本文編號：2146919