發(fā)布時(shí)間：2018-07-26 18:30

【摘要】：目的:研究乳腺癌患者術(shù)后發(fā)生下肢深靜脈血栓(deep venous thrombosis,DVT)的危險(xiǎn)因素,分析血栓風(fēng)險(xiǎn)評(píng)估模型的臨床價(jià)值。方法:回顧性分析2013年1月至2016年6月天津醫(yī)科大學(xué)腫瘤醫(yī)院703例術(shù)后發(fā)生血栓的患者為血栓組,通過(guò)系統(tǒng)抽樣法選取對(duì)照組706例,分析乳腺癌患者術(shù)后發(fā)生下肢DVT的危險(xiǎn)因素,并比較Khorana及Caprini血栓風(fēng)險(xiǎn)評(píng)估模型的預(yù)測(cè)價(jià)值。結(jié)果:比較血栓組與對(duì)照組的年齡、BMI≥30 kg/m~2、手術(shù)切除活檢確診、接受新輔助化療、手術(shù)時(shí)間2 h、治療前脂蛋白a(Lpa)475.5 mg/L、血漿蛋白C(PC)102.5%、血漿凝血因子Ⅷ(FⅧ)129.8%及D-二聚體(D-D)289.99 ng/m L,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組患者的Khorana風(fēng)險(xiǎn)評(píng)估模型進(jìn)行比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P=0.207);兩組患者的Caprini風(fēng)險(xiǎn)評(píng)估模型進(jìn)行比較,差異具有統(tǒng)計(jì)學(xué)意義(P0.001)。結(jié)論:年齡、BMI≥30 kg/m~2、手術(shù)切除活檢確診、接受新輔助化療、手術(shù)時(shí)間2 h、治療前Lpa475.5 mg/L、PC102.5%、FⅧ129.8%及D-D289.99 ng/m L是乳腺癌術(shù)后發(fā)生下肢DVT的獨(dú)立危險(xiǎn)因素,Caprini評(píng)估模型可能導(dǎo)致乳腺癌患者血栓風(fēng)險(xiǎn)評(píng)估偏高,應(yīng)進(jìn)一步探究更加適合乳腺癌患者血栓的風(fēng)險(xiǎn)評(píng)估模型。
[Abstract]:Objective: to study the risk factors of (deep venous thromboembolism (DVT) in patients with breast cancer after operation, and to analyze the clinical value of thrombus risk assessment model. Methods: from January 2013 to June 2016, 703 patients with postoperative thrombus in Tianjin Medical University Oncology Hospital were analyzed retrospectively. 706 patients in the control group were selected by systematic sampling. To analyze the risk factors of lower extremity DVT in breast cancer patients, and to compare the predictive value of Khorana and Caprini thrombus risk assessment models. Results: the age and BMI of thrombus group and control group were more than 30 kg / m ~ (-2), confirmed by surgical resection and biopsy, and accepted neoadjuvant chemotherapy. After 2 hours of operation, lipoprotein a (Lpa) 475.5 mg / L, plasma protein C (PC) 102.5, plasma coagulation factor 鈪，

本文編號(hào)：2146919