發(fā)布時(shí)間：2018-07-10 02:19

  本文選題：細(xì)胞衰老 + P~(INKa)　； 參考：《廣東醫(yī)學(xué)》2017年24期

【摘要】：目的探討衰老標(biāo)志物衰老相關(guān)β半乳糖苷酶(SA-β-gal)及P16~(INK4A)在大腸腺瘤及大腸癌中的表達(dá)及其臨床意義。方法應(yīng)用SA-β-gal染色法和免疫組織法分別檢測30例大腸腺瘤及腺瘤旁正常組織、48例大腸癌組織及癌旁組織中SA-β-gal及P16~(INK4A)的表達(dá)。分析和比較不同病理特征的大腸腺瘤及大腸癌中SA-β-gal和P16~(INK4A)的表達(dá)情況。結(jié)果大腸腺瘤組織中SA-β-gal和P16~(INK4a)的表達(dá)明顯高于大腸癌組織及腺瘤旁正常組織,大腸癌組織中SA-β-gal和P16~(INK4a)的表達(dá)明顯低于癌旁正常組織。SA-β-gal在絨毛管狀腺瘤、1 cm的腺瘤、進(jìn)展期腺瘤中低表達(dá),在低分化腺癌、有遠(yuǎn)處轉(zhuǎn)移、Ⅳ期的大腸癌中低表達(dá)。P16~(INK4a)在無淋巴結(jié)轉(zhuǎn)移、Ⅰ、Ⅱ期大腸癌中高表達(dá)。結(jié)論 SA-β-gal及P16~(INK4a)在不同大腸組織中的表達(dá)情況提示細(xì)胞衰老可能作為抑制途徑參與到腺瘤發(fā)生癌變的過程中。推測SA-β-gal的檢測可能作為預(yù)警高風(fēng)險(xiǎn)癌前病變的標(biāo)志物,P16~(INK4a)可作為大腸癌預(yù)后良好的指標(biāo)。
[Abstract]:Objective to investigate the expression and clinical significance of senescence-associated 尾 -galactosidase (SA- 尾 -gal) and P16 ~ (INK4A) in colorectal adenoma and colorectal carcinoma. Methods SA- 尾 -gal staining and immunohistochemical method were used to detect the expression of SA- 尾 -gal and P16INK4A in 30 cases of colorectal adenoma and 48 cases of normal tissues adjacent to adenoma. The expression of SA- 尾 -gal and P16INK4A in colorectal adenoma and colorectal carcinoma with different pathological features were analyzed and compared. Results the expression of SA- 尾 -gal and P16 ~ (INK4a) in colorectal adenoma was significantly higher than that in colorectal carcinoma and adjacent normal tissue, and the expression of SA- 尾 -gal and P16 ~ (INK4a) in colorectal carcinoma tissue was significantly lower than that in adjacent normal tissue. The expression of P16 ~ (INK4a) in advanced adenoma was low, and in poorly differentiated adenocarcinoma with distant metastasis. In stage 鈪，

本文編號(hào)：2111640