本文選題：自擬理氣和胃湯 + 胃癌術后��； 參考：《黑龍江中醫(yī)藥大學》2017年碩士論文

【摘要】：目的:探討自擬理氣和胃湯聯(lián)合XELOX方案對胃癌術后肝胃不和型患者的臨床療效。方法:將符合納入標準的90例患者隨機分為治療組與對照組,兩組各45例患者。對照組給予XELOX方案化療(卡培他濱1000mg/m2,口服Bid,d1-d14;奧沙利鉑130mg/m2,iv d1),治療組在對照組治療的基礎上加服自擬理氣和胃湯(300ml,分早晚兩次口服)。兩組均以21天為一個周期,治療兩個周期。觀察患者中醫(yī)證候評分、腫瘤標志物、KPS評分、毒副反應等變化。結果:1.治療后,兩組患者的中醫(yī)證候評分較治療前均下降,差異有統(tǒng)計學意義(p0.05)。2.治療后,兩組患者的腫瘤標志物(CEA、CA19-9、CA72-4)與治療前相比均降低,差異有統(tǒng)計學意義(p0.05)。3.治療后,兩組患者的KPS評分與治療前相比均提高,差異有統(tǒng)計學意義(p0.05)。治療組與對照組相比,治療組KPS評分比對照組提高更為顯著(p0.05)。4.治療后,兩組患者均有不同程度的毒副反應。治療組白細胞、血紅蛋白減少發(fā)生率、消化道反應發(fā)生率低于對照組,差異有統(tǒng)計學意義(p0.05):5.治療組手足綜合征、神經毒性、血小板減少發(fā)生率雖與對照組相比降低,但差異無統(tǒng)計學意義(p0.05)。結論:1.自擬理氣和胃湯聯(lián)合XELOX方案治療胃癌術后肝胃不和型患者較單純XELOX方案相比,可降低患者血清腫瘤標志物水平,提高臨床療效。2.自擬理氣和胃湯聯(lián)合XELOX方案較單純XELOX方案能夠改善患者臨床癥狀,提高其生活質量。3.自擬理氣和胃湯可改善XELOX方案所導致的骨髓抑制及減輕消化道反應。
[Abstract]:Objective: to investigate the clinical effect of self-made decoction of regulating qi and stomach combined with XELOX regimen in patients with hepatogastric disharmony after operation of gastric cancer. Methods: 90 patients were randomly divided into treatment group (n = 45) and control group (n = 45). The control group was treated with XELOX regimen (capecitabine 1000mg / m2, Bidd1-d14; oxaliplatin 130mg / m2 iv D1). The treatment group was treated with self-made decoction of regulating qi and stomach (300ml, twice in the morning and evening). Both groups were treated with 21 days for one cycle and two cycles for treatment. The changes of TCM syndrome score, tumor marker KPS score and toxicity were observed. The result is 1: 1. After treatment, the TCM syndrome scores of the two groups decreased compared with those before treatment, the difference was statistically significant (p0.05). 2. After treatment, the tumor markers (CEACA19-9, CA72-4) in both groups were significantly lower than those before treatment (p0.05). After treatment, the KPS scores of the two groups were significantly higher than those before treatment (p0.05). Compared with the control group, the KPS score in the treatment group was significantly higher than that in the control group (p0.05). 4. After treatment, the two groups of patients have varying degrees of toxic side effects. The incidence of leukocyte, hemoglobin reduction and digestive tract reaction in the treatment group was lower than that in the control group (p0.05): 5. The incidence of hand and foot syndrome, neurotoxicity and thrombocytopenia in the treatment group was lower than that in the control group, but the difference was not statistically significant (p0.05). Conclusion 1. Compared with the simple XELOX regimen, the self-made regimen of regulating qi and stomach decoction combined with XELOX can reduce the level of serum tumor markers and improve the clinical efficacy. 2. Compared with XELOX alone, self-made regimen of regulating qi and stomach decoction combined with XELOX can improve the clinical symptoms and improve the quality of life of the patients. Self-made decoction of regulating qi and stomach can improve bone marrow depression and alleviate digestive tract reaction caused by XELOX regimen.
【學位授予單位】：黑龍江中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R735.2

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