本文選題：顱底腫瘤 + 畸胎癌肉瘤��； 參考：《臨床與實驗病理學雜志》2017年11期

【摘要】：目的探討發(fā)生于顱底的畸胎癌肉瘤臨床病理特征、診斷與鑒別診斷。方法采用形態(tài)學觀察及免疫組化En Vision兩步法對2例發(fā)生于顱底的畸胎癌肉瘤進行分析,并復習相關文獻。結(jié)果例1男性,以顱底占位就診;例2女性,以鞍區(qū)占位就診;例1患者2年后復發(fā)1次,同時在復發(fā)當年并發(fā)右腎血管平滑肌脂肪瘤,例2隨訪無復發(fā)。腫瘤組織成分復雜,形態(tài)多樣,可見未成熟的鱗狀細胞巢及腺樣結(jié)構(gòu)和畸胎瘤成分以及肉瘤成分,間質(zhì)中可見未分化/原始間葉細胞,免疫組化標記顯示不同成分表達不同標志物;其與鼻腔鼻竇畸胎癌肉瘤形態(tài)與免疫表型相似。結(jié)論畸胎癌肉瘤屬于罕見的惡性腫瘤,好發(fā)于鼻腔鼻竇,發(fā)生于顱底者罕見,臨床易誤診,診斷及鑒別診斷主要依靠病理形態(tài)觀察和免疫表型分析。
[Abstract]:Objective to investigate the clinicopathological features, diagnosis and differential diagnosis of teratosarcoma in the skull base. Methods two cases of teratosarcoma in the skull base were analyzed by morphological observation and immunohistochemical en Vision method, and the related literatures were reviewed. Results case 1, male, with skull base occupying, case 2, female, with Sellar area, case 1 recurred once 2 years later, at the same time, right renal angiomyolipoma was complicated with right renal angiomyolipoma in the year of recurrence. No recurrence was found in case 2. The tumor tissue components were complex and varied, with immature squamous cell nests and adenoid structures, teratoma components and sarcoma components, and undifferentiated / primitive mesenchymal cells in the stroma. The expression of different markers was similar to the morphology and immunophenotype of teratosarcoma of nasal cavity and paranasal sinus. Conclusion teratosarcoma is a rare malignant tumor, which usually occurs in the nasal cavity and paranasal sinus, and is rare in the skull base. The diagnosis and differential diagnosis of teratosarcoma are mainly based on pathological observation and immunophenotypic analysis.
【作者單位】： 江西省贛州市人民醫(yī)院病理科;
【基金】：江西省衛(wèi)生計劃委科技計劃(20157173) 贛州市科技計劃(GZ2015ZSF111)
【分類號】：R739.4
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本文編號：2109197