本文選題：HIF-α + rs　； 參考：《中國肺癌雜志》2017年03期

【摘要】：背景與目的低氧誘導(dǎo)因子-1α(hypoxia inducible factor 1α,HIF-1α)與肺癌的惡化與轉(zhuǎn)移有關(guān),但HIF-1α的單核苷酸多態(tài)性(single nucleotide polymorphisms,SNPs)與肺癌易感性的研究仍較少。本研究旨在探討室內(nèi)空氣污染、rs2057482多態(tài)性與福建漢族肺癌易感性的關(guān)系。方法采用以醫(yī)院為基礎(chǔ)的病例對(duì)照設(shè)計(jì),選擇2006年1月-2012年12月在福建醫(yī)科大學(xué)附屬第一醫(yī)院、協(xié)和醫(yī)院和南京軍區(qū)福州總醫(yī)院的胸外科及呼吸內(nèi)科病理確診的漢族新發(fā)原發(fā)性肺癌患者1,096例,選取無腫瘤病史、同期前往醫(yī)院其他科室探視的患者漢族親友和社區(qū)漢族人群1,110例,進(jìn)行問卷調(diào)查。應(yīng)用MALDI-TOF-MS技術(shù)對(duì)所有研究對(duì)象HIF-1α基因rs2057482位點(diǎn)多態(tài)性進(jìn)行基因分型。結(jié)果攜帶有HIF-1αrs2057482位點(diǎn)T基因型的人群更容易罹患小細(xì)胞癌[TT vs CC的比值比(odds ratio,OR)值為1.725,95%CI:1.047-2.842]。調(diào)整一般情況和肺癌有關(guān)影響因素后,在共顯性遺傳模型中,暴露于被動(dòng)吸煙的rs2057482 TT攜帶者肺癌患病風(fēng)險(xiǎn)是CC攜帶者的2.195倍(95%CI:1.038-4.643)。在顯性遺傳模型中,有腫瘤家族史的rs2057482 T基因攜帶者肺癌患病風(fēng)險(xiǎn)是C基因攜帶者的1.911倍(95%CI:1.121-3.258)。在隱性遺傳模型中,肺部疾病史的rs2057482 TT攜帶者的肺癌患病風(fēng)險(xiǎn)是TC+CC攜帶者的0.159倍(95%CI:0.028-0.920)。在加性遺傳模型中,有腫瘤家族史的rs2057482 TC+TT攜帶者的肺癌患病風(fēng)險(xiǎn)是CC攜帶者的1.542倍(95%CI:1.107-2.340)。結(jié)論 HIF-1αrs2057482位點(diǎn)可能與肺癌易感性存在一定關(guān)聯(lián)。
[Abstract]:Background & objective hypoxic inducible factor 1 偽 (hypoxia inducible factor 1 偽 (HIF-1 偽) is associated with the deterioration and metastasis of lung cancer, but the single nucleotide polymorphisms (single nucleotide polymorphismsns of HIF-1 偽 and the susceptibility to lung cancer are still less studied. The aim of this study was to investigate the relationship between the polymorphism of indoor air pollution rs2057482 and the susceptibility to lung cancer in Fujian Han nationality. Methods A case-control design based on hospital was used to select the first affiliated Hospital of Fujian Medical University from January 2006 to December 2012. 1096 newly diagnosed Han patients with primary lung cancer were selected from the Department of Thoracic surgery and the Department of Respiratory Medicine of Xianghe Hospital and Fuzhou General Hospital of Nanjing military region. At the same time, 1110 cases of relatives and friends of Han nationality and Han nationality in community were investigated by questionnaire. Rs2057482 polymorphism of HIF-1 偽 gene was genotyped by MALDI-TOF-MS. Results people with HIF-1 偽 rs2057482 locus T genotype were more likely to develop small cell carcinoma [odds ratioor (TT vs CC) = 1.725 / 95 CI: 1.047-2.842]. After adjusting for general conditions and factors related to lung cancer, the risk of lung cancer in rs2057482 TT carriers exposed to passive smoking was 2.195 times higher than that of CC carriers (95 CI: 1.038-4.643) in the codominant genetic model. In the dominant genetic model, rs2057482 T carriers with a family history of cancer were 1.911 times more likely to develop lung cancer than those with C gene (95 CI: 1.121-3.258). In the recessive genetic model, the risk of lung cancer in rs2057482 TT carriers with history of lung disease was 0.159 times higher than that in TC CC carriers (95 CI: 0.028-0.920). In the additive genetic model, the risk of lung cancer in rs2057482 TTC TT carriers with a family history of cancer was 1.542 times higher than that in CC carriers (95 CI: 1.107-2.340). Conclusion HIF-1 偽 rs2057482 may be associated with lung cancer susceptibility.
【作者單位】： 福建醫(yī)科大學(xué)公共衛(wèi)生學(xué)院流行病與衛(wèi)生統(tǒng)計(jì)學(xué)系;福建醫(yī)科大學(xué)附屬第一醫(yī)院胸外科;
【基金】：國家自然科學(xué)基金青年項(xiàng)目(No.81402738) 福建省自然科學(xué)基金面上項(xiàng)目(No.2016J01355) 福建省衛(wèi)生計(jì)生委青年科研項(xiàng)目(No.2014-1-37)資助~~
【分類號(hào)】：R734.2

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 唐錄英,任澤舫,莊志雄,劉曉合,蘇祖蘭,黃鈺;聚腺苷二磷酸核糖聚合酶假基因多態(tài)性分布及其與肺癌易感性的關(guān)系[J];中華醫(yī)學(xué)遺傳學(xué)雜志;2002年02期

2 崔紅梅,尹立紅,浦躍樸;線粒體DNA 16519 T→C變異與肺癌易感性的關(guān)系[J];環(huán)境與職業(yè)醫(yī)學(xué);2003年02期

3 邵國光;馬忠余;李健強(qiáng);;單核苷酸多態(tài)性與肺癌易感性關(guān)系的研究進(jìn)展[J];中國肺癌雜志;2006年02期

4 燕貞;吳擁軍;吳逸明;;細(xì)胞色素P450 2D6與吸煙所致肺癌易感性的關(guān)系研究[J];衛(wèi)生研究;2007年01期

5 安明;趙國君;;GSTT1基因多態(tài)性與肺癌易感性研究進(jìn)展[J];內(nèi)蒙古醫(yī)學(xué)院學(xué)報(bào);2010年S3期

6 高堅(jiān)瑞,任春蘭,陸榮柱;細(xì)胞色素P_(450)2D6G-A突變與肺癌易感性關(guān)系研究[J];鎮(zhèn)江醫(yī)學(xué)院學(xué)報(bào);1997年03期

7 趙魯杭,陳樞青,余國偉,馬勝林,李滸;細(xì)胞色素P450 2C19基因多態(tài)性與肺癌易感性的關(guān)系[J];中華結(jié)核和呼吸雜志;1999年11期

8 聶立紅 ,王聲ng ,胡毅玲;肺癌易感性的分子流行病學(xué)研究[J];中國公共衛(wèi)生;2002年07期

9 顧艷斐;代謝酶基因多態(tài)性與肺癌易感性關(guān)系的研究進(jìn)展[J];中國肺癌雜志;2002年02期

10 陳漫霞,陳思東,汪保國,蔡旭玲,冼雪珍;細(xì)胞色素P450 2E1基因多態(tài)性與肺癌易感性的研究[J];四川腫瘤防治;2003年03期

相關(guān)會(huì)議論文 前10條

1 常福厚;張志賢;尹琴;馬佳;王敏杰;;GSTP1基因多態(tài)性與肺癌易感性關(guān)系的研究[A];中國藥理學(xué)會(huì)第十次全國學(xué)術(shù)會(huì)議專刊[C];2009年

2 丁建華;曹海霞;李蘇平;吳建中;高長明;劉燕婷;;醇醛脫氫酶基因多態(tài)及飲酒習(xí)慣與胃癌易感性[A];全國腫瘤流行病學(xué)和腫瘤病因?qū)W學(xué)術(shù)會(huì)議論文集[C];2011年

3 常福厚;張志賢;白圖雅;王敏杰;范蕾;馬佳;;CYP2C19基因多態(tài)性與內(nèi)蒙古蒙漢族人群肝癌易感性關(guān)系的研究[A];轉(zhuǎn)化醫(yī)學(xué)研討會(huì)論文集[C];2010年

4 徐[?;金鴻雁;李斌;;FSHR基因Ala307Thr單核甘酸多態(tài)性與漿液性卵巢癌易感性的關(guān)聯(lián)研究[A];中華醫(yī)學(xué)會(huì)第十次全國婦產(chǎn)科學(xué)術(shù)會(huì)議婦科腫瘤會(huì)場（婦科腫瘤學(xué)組、婦科病理學(xué)組）論文匯編[C];2012年

5 于蓮珍;郜恒駿;施瑞華;;胃癌易感性基因檢測芯片的臨床初步應(yīng)用研究[A];中華醫(yī)學(xué)會(huì)第七次全國消化病學(xué)術(shù)會(huì)議論文匯編（下冊(cè)）[C];2007年

6 王琪;胡偉國;宋啟斌;;代謝酶基因多態(tài)性與肺癌易感性的研究進(jìn)展[A];第四屆湖北省抗癌協(xié)會(huì)青年委員會(huì)學(xué)術(shù)交流會(huì)論文集[C];2012年

7 鮑倩;張穎;王書奎;;白細(xì)胞介素10基因啟動(dòng)子區(qū)多態(tài)性與胃癌易感性的關(guān)系研究[A];2010’全國腫瘤分子標(biāo)志及應(yīng)用學(xué)術(shù)研討會(huì)暨第五屆中國中青年腫瘤專家論壇論文匯編[C];2010年

8 浦躍樸;尹立紅;林嬪嬪;印木泉;;外源物代謝酶基因多態(tài)與肺癌易感性關(guān)系的研究[A];面向21世紀(jì)的科技進(jìn)步與社會(huì)經(jīng)濟(jì)發(fā)展（下冊(cè)）[C];1999年

9 江s，

本文編號(hào)：2106504