本文關(guān)鍵詞：干擾素在腫瘤免疫中的雙重作用，由筆耕文化傳播整理發(fā)布。

干擾素在腫瘤免疫中的雙重作用

Dual role of interferons in tumor immunology

[1] [2]

Chen Kun,Cao Xuetao（Institute of Immunology, School of Medicine, Zhejiang University, Hangzhou 310031;Institute of Immunology, School of Medicine, Zhejiang University, Hangzhou 310

[1]浙江大學(xué)醫(yī)學(xué)院免疫學(xué)研究所,浙江杭州310031; [2]第二軍醫(yī)大學(xué)免疫學(xué)研究所暨醫(yī)學(xué)免疫學(xué)國家重點實驗室,上海200433

文章摘要：干擾素（interferon，IFN）是最早發(fā)現(xiàn)的一類抗病毒感染的細(xì)胞因子，主要分為3類，即Ⅰ型、Ⅱ型和Ⅲ型IFN。IFN可通過JAK-STAT依賴和非依賴的的信號途徑參與機體多種生命活動過程，如抗病毒感染、調(diào)節(jié)細(xì)胞增殖、調(diào)節(jié)機體免疫應(yīng)答等。此外，IFN在腫瘤免疫中也發(fā)揮著重要的作用。Ⅰ型IFN可以激活DC釋放腫瘤壞死因子相關(guān)凋亡誘導(dǎo)配體（tumor necrosis factor-related apoptosis inducing ligand，TRAIL），從而增強NK細(xì)胞的細(xì)胞毒活性，或直接殺傷腫瘤細(xì)胞；Ⅱ型IFN通過活化CTL殺傷腫瘤細(xì)胞，并通過提高腫瘤細(xì)胞主要組織相容性復(fù)合物（major histocompatibility complex，MHC）類分子的表達以增強CTL對腫瘤的識別，或通過調(diào)節(jié)細(xì)胞的代謝間接抑制腫瘤的進展。但在一定條件下，IFN又可以上調(diào)Treg、Th17細(xì)胞的數(shù)量，誘導(dǎo)髓系抑制性細(xì)胞（myeloid-derived suppressor cell，MDSC）在腫瘤微環(huán)境中的浸潤，從而發(fā)揮免疫抑制效應(yīng)，促進腫瘤細(xì)胞的免疫逃逸。因此，IFN在腫瘤免疫中是一把“雙刃劍”。深入研究IFN在腫瘤免疫中的作用及其機制，探索以IFN為基礎(chǔ)的腫瘤治療新途徑（如IFN為主的免疫化學(xué)療法），對改善腫瘤治療效果具有重要的指導(dǎo)意義。

Abstr：Interferon （IFN） was early discovered as a family of antiviral cytokines which includes three main classes： type I IFNs, type Ⅱ and type Ⅲ . IFN plays critical roles in multiple biological activities such as anti-virus infection, regulation of cell proliferation and immunological response through JAK-STAT dependent or independent signaling pathways. In addition, IFNs also take an important role in tumor immunology. Type Ⅰ IFNs can activate DC cells to relase tumor necrosis factor-related apoptosis inducing ligand （TRAIL）, which can enhance the cytotoxicity of NK cells or kill tumor cellls directly. Meanwhile, type Ⅱ IFNs can activate CTL to kill tumor cells, and can enhance identification of CTL to tumors by increasing the expression of major histocompatibility complex （MHC） or indirectly inhibit tumor progression through regulating cell metabolism. However, under certain conditions, IFN-γ was found to increase the numbers of Treg and Th17 cells and induce MDSC infiltrating in the tumor microenvironment that can suppress the function of immune system and “help” tumor cells escape from immunosurveillance. Therefore, IFNs participate in tumor immunology as a “double-edged sword”. Further studies on the function and mechanism of IFNs in tumor immunolgy, and exploration of new IFN-based cancer treatment （such as IFN-based immuno-chemotherapy） are significant guides to improve tumor treatment.

文章關(guān)鍵詞：

Keyword：:interferon tumor immunology dual role immunotherapy

課題項目：國家自然科學(xué)基金資助項目（No. 81230074）

  本文關(guān)鍵詞：干擾素在腫瘤免疫中的雙重作用，由筆耕文化傳播整理發(fā)布。