發(fā)布時(shí)間：2018-07-01 12:31

  本文選題：腫瘤 + 歐洲五維健康量表��； 參考：《腫瘤》2017年09期

【摘要】：目的:本研究依托2013—2014年在北京市城市地區(qū)開(kāi)展的食管癌、胃癌、結(jié)直腸癌、肝癌、肺癌和乳腺癌的人群篩查和早診早治現(xiàn)場(chǎng),采用歐洲五維健康量表EQ-5D-3L和癌癥治療功能評(píng)價(jià)量表(Functional Assessment of Cancer Therapy,FACT)對(duì)癌癥及癌前病變患者的健康相關(guān)生活質(zhì)量進(jìn)行測(cè)量,并分析EQ-5D-3L和FACT針對(duì)北京市癌癥人群的信度及效度。方法:采用EQ-5D-3L和FACT同時(shí)對(duì)1 001例癌癥及癌前病變患者進(jìn)行測(cè)量,對(duì)EQ-5D-3L及FACT的結(jié)果進(jìn)行Cronbachα系數(shù)的內(nèi)部一致性信度檢驗(yàn),對(duì)FACT采用公因子進(jìn)行結(jié)構(gòu)效度分析,對(duì)EQ-5D-3L和FACT進(jìn)行對(duì)比以實(shí)現(xiàn)聚合效度的分析。結(jié)果 :對(duì)于肺癌、乳腺癌、結(jié)直腸癌、食管癌、肝癌和胃癌這6種癌癥,EQ-5D-3L的Cronbachα系數(shù)分別為0.846、0.805、0.877、0.862、0.793和0.844,FACT的Cronbachα系數(shù)分別為0.935、0.916、0.950、0.952、0.915和0.953。在結(jié)構(gòu)效度分析中,FACT累積解釋方差分別為64.28%、65.15%、71.43%、67.21%、64.76%和70.56%。對(duì)比FACT,EQ-5D-3L的聚合效度分別為0.592、0.503、0.715、0.672、0.561和0.444,EQ-視覺(jué)模擬量表的聚合效度分別為0.553、0.606、0.576、0.579、0.361和0.364。結(jié)論 :EQ-5D-3L和FACT應(yīng)用于北京市癌癥及癌前病變患者的生活質(zhì)量評(píng)估,具有較好的信度。FACT 6種癌癥量表的結(jié)構(gòu)效度較好,肺癌、乳腺癌、結(jié)直腸癌、肝癌和食管癌的EQ-5D-3L量表效度也較好,而胃癌及癌前病變的EQ-5D-3L量表效度一般。
[Abstract]:Objective: this study was based on screening and early diagnosis and treatment of esophageal cancer, gastric cancer, colorectal cancer, liver cancer, lung cancer and breast cancer in urban areas of Beijing from 2013 to 2014. EQ-5D-3L and functional Assessment of Cancer Therapeutics were used to measure the health-related quality of life in patients with cancer and precancerous lesions. The reliability and validity of EQ-5D-3L and fact for cancer patients in Beijing were analyzed. Methods: 1 001 patients with cancer and precancerous lesions were measured by EQ-5D-3L and fact. The results of EQ-5D-3L and fact were tested for the internal consistency reliability of Cronbach 偽 coefficients, and the structural validity of the common factors were analyzed. EQ-5 D-3 L and fact were compared to achieve the analysis of polymerization validity. Results: for lung cancer, breast cancer, colorectal cancer, esophageal cancer, liver cancer and gastric cancer, the Cronbach 偽 coefficients of EQ-5D-3L were 0.846 ~ 0.805 ~ (0.877) ~ 0.862 ~ 0.793 and 0.84 ~ (4) FACT, respectively. The Cronbach 偽 coefficients of six kinds of cancer were 0.9350.9160.9500.9520.915 and 0.95353 respectively. In the structural validity analysis, the variance of the cumulative interpretation of facts was 64.285.15 and 71.437.21, 64.76% and 70.5656%, respectively. Compared with facts EQ-5D-3L, the polymerization validity of the EQ-5D-3L was 0.592X 0.503U 0.7150.672U 0.561 and 0.444EQ- visual analogue scale 0.5530.6060.5760.5790.361 and 0.364 respectively. Conclusion the quality of life of patients with cancer and precancerous lesions in Beijing was evaluated by using the weight EQ-5D-3L and fact. The reliability of the six cancer scales was good. The structural validity of the six cancer scales was good, lung cancer, breast cancer, colorectal cancer, lung cancer, breast cancer and colorectal cancer. The validity of EQ-5D-3L scale for liver cancer and esophageal carcinoma was also good, while the validity of EQ-5D-3L scale for gastric cancer and precancerous lesions was moderate.
【作者單位】： 中國(guó)醫(yī)學(xué)科學(xué)院醫(yī)學(xué)信息研究所公共衛(wèi)生信息研究室;
【分類(lèi)號(hào)】：R73-31

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