發(fā)布時間：2018-07-01 11:19

  本文選題：乳腺癌 + 雌激素受體β�。� 參考：《新疆醫(yī)科大學》2015年碩士論文

【摘要】：目的：探討雌激素受體(ER)β基因Rsal位點基因多態(tài)性與新疆維、漢民族乳腺癌易感性的關系。方法：應用聚合酶鏈反應-限制性內切酶片段長度多態(tài)性(PCR-RFLP)方法檢測130例維吾爾族女性乳腺癌患者、125例維吾爾族健康女性、120例漢族女性乳腺癌患者及118例漢族健康女性的ERβ基因Rsal位點多態(tài)性,比較該位點多態(tài)性與新疆維、漢女性乳腺癌易感性的關系。結果：維、漢兩民族病例組、對照組基因型分布及等位基因頻率均具有顯著差異(P0.05)。在維吾爾族組中,與rr基因型相比,攜帶Rr基因型者OR值為0.950,95% CI 0.529-1.707,P0.05,差異無統(tǒng)計學意義；在漢族組中,病例組與對照組的基因型分布差異及等位基因頻率均有統(tǒng)計學差異(P0.05),相對于rr基因型,攜帶Rr基因型顯著降低了乳腺癌的發(fā)病風險(OR 0.370,95% CI 0.279-0.792,P0.05),差異有統(tǒng)計學意義。攜帶Rr基因型在BMI≥25Kg/m2、無腫瘤家族史的維吾爾族婦女中乳腺癌的發(fā)病風險降低,在年齡為36～49歲、初潮年齡為13～16歲、無多產史或BMI25Kg/m2的漢族婦女中乳腺癌的發(fā)病風險降低,ERβ基因多態(tài)性與ER、PR、Her-2表達均無相關性(P0.05)。結論：病例組、對照組中維、漢兩民族基因型分布及等位基因頻率具有顯著差異。在維、漢人群中,ERβ基因Rsal位點多態(tài)性與乳腺癌的發(fā)生有關。
[Abstract]:Objective: to investigate the relationship between the polymorphism of estrogen receptor (ER) 尾 gene Rsal locus and the susceptibility to breast cancer in Uygur and Han ethnic groups in Xinjiang. Methods: polymerase chain reaction-restriction endonuclease fragment length polymorphism (PCR-RFLP) was used to detect 130 Uygur women with breast cancer, 125 healthy Uygur women with breast cancer and 120 Han women with breast cancer and 118 healthy women with Han nationality. The polymorphism of ER 尾 gene Rsal locus in healthy women, To compare the relationship between the polymorphism of this locus and the susceptibility to breast cancer in Weiwei and Han Chinese women. Results: there were significant differences in genotype distribution and allele frequency between the two ethnic groups (P0.05). In Uygur group, the OR value of Rr genotype was 0.950% 95% CI 0.529-1.707 P0.05.The difference was not significant in Han nationality group. The genotype distribution and allele frequency were significantly different between the case group and the control group (P0.05). Compared with the rr genotype, the risk of breast cancer was significantly decreased by carrying the Rr genotype (OR 0.370,95% CI 0.279-0.792P 0.05), and the difference was statistically significant. The risk of breast cancer in Uygur women with BMI 鈮，

本文編號：2087612