本文選題：前列腺癌 + 生存時間�。� 參考：《中華男科學(xué)雜志》2017年04期

【摘要】：目的:探討應(yīng)激激活蛋白激酶(JNK)與磷酸化JNK(p-JNK)在晚期前列腺癌(PCa)和良性前列腺增生(BPH)中的表達及意義。方法:收集晚期PCa組織蠟塊40例,BPH組織蠟塊21例。免疫組化法檢測組織中JNK和p-JNK蛋白表達,并分析其與晚期PCa和BPH的關(guān)系,及與晚期PCa患者病理特征的關(guān)系。結(jié)果:BPH組與PCa組JNK蛋白陽性表達率分別為42.86%、52.50%,無統(tǒng)計學(xué)差異(P0.05)。在未轉(zhuǎn)移癌和轉(zhuǎn)移癌、Gleason≤7和Gleason7、PSA≤20μg/L和PSA20μg/L、生存時間5年和生存時間≤5年P(guān)Ca中的JNK蛋白陽性表達率分別為53.85%和51.85%、58.82%和47.82%、57.14%和51.52%、60.00%和45.00%,無統(tǒng)計學(xué)差異(P0.05)。p-JNK蛋白在BPH組與PCa組中的陽性表達率分別為33.33%、35.00%,無統(tǒng)計學(xué)差異(P0.05)。在未轉(zhuǎn)移癌和轉(zhuǎn)移癌、Gleason≤7和Gleason7、PSA≤20μg/L和PSA20μg/L PCa中的p-JNK蛋白陽性表達率分別為30.77%和37.03%、35.29%和34.78%、43.75%和10.93%,無統(tǒng)計學(xué)差異(P0.05)。生存時間5年組pJNK陽性率為50%,生存時間≤5年組p-JNK陽性率為20.00%,有統(tǒng)計學(xué)差異(P0.05)。結(jié)論:p-JNK高表達的PCa組生存時間長,并與PCa的預(yù)后相關(guān)。
[Abstract]:Objective: to investigate the expression and significance of stress activated protein kinase (JNK) and phosphorylated JNK (p-JNK) in advanced prostate cancer (PCA) and benign prostatic hyperplasia (BPH). Methods: a total of 40 cases of BPH tissue wax block in late stage were collected. The expression of JNK and p-JNK protein was detected by immunohistochemical method. The relationship between JNK and p-JNK protein and the pathological characteristics of late PCA was analyzed. Results the positive expression rates of JNK protein in BPH group and PCA group were 42.86 and 52.50 respectively (P0.05). In Gleason 鈮，

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