本文選題：鋅指蛋白 + 結(jié)腸癌��； 參考：《中國(guó)現(xiàn)代醫(yī)學(xué)雜志》2017年08期

【摘要】：目的檢測(cè)鋅指蛋白217(ZNF217)在結(jié)腸癌中的表達(dá),分析ZNF217的表達(dá)水平與結(jié)腸癌患者臨床病理特征及結(jié)腸癌患者生存與預(yù)后的相關(guān)性。方法利用免疫組織化學(xué)方法檢測(cè)84例結(jié)腸癌患者組織標(biāo)本及相應(yīng)癌旁組織中ZNF217的表達(dá)水平,并利用Spearman秩相關(guān)、K-M曲線及Cox比例風(fēng)險(xiǎn)回歸模型等統(tǒng)計(jì)方法分析ZNF217在結(jié)腸癌中的臨床相關(guān)性。結(jié)果免疫組化結(jié)果發(fā)現(xiàn)結(jié)腸癌組織中ZNF217陽性表達(dá)率高于癌旁組織。Spearman秩相關(guān)顯示ZNF217的表達(dá)水平與結(jié)腸癌患者TNM分期和淋巴轉(zhuǎn)移情況呈正相關(guān),且與其他結(jié)腸癌患者臨床病理特征無相關(guān)性。K-M曲線顯示ZNF217表達(dá)水平與結(jié)腸癌患者術(shù)后總體生存率及無進(jìn)展生存率呈負(fù)相關(guān)。Cox風(fēng)險(xiǎn)比例模型顯示ZNF217可作為判斷結(jié)腸癌預(yù)后獨(dú)立的預(yù)測(cè)指標(biāo)。結(jié)論 ZNF217在結(jié)腸癌組織中表達(dá)升高,且可作為判斷結(jié)腸癌患者生存及預(yù)后的獨(dú)立的潛在分子指標(biāo)。
[Abstract]:Objective to detect the expression of zinc finger protein 217 (ZNF217) in colon cancer, and to analyze the relationship between the expression of ZNF217 and clinicopathological features, survival and prognosis of colon cancer patients. Methods Immunohistochemical method was used to detect the expression of ZNF217 in 84 patients with colon cancer and its adjacent tissues. The clinical correlation of ZNF217 in colon cancer was analyzed by Spearman rank correlation K-M curve and Cox proportional risk regression model. Results the positive expression rate of ZNF217 in colon cancer tissue was higher than that in paracancerous tissue. Spearman rank correlation showed that the expression level of ZNF217 was positively correlated with TNM stage and lymphatic metastasis of colon cancer patients. There was no correlation with clinicopathological features of other colon cancer patients. K-M curve showed that ZNF217 expression level was negatively correlated with overall survival rate and progression free survival rate of colon cancer patients after operation. Cox risk ratio model showed that ZNF217 could be used as a predictor of colon. An independent predictor of cancer prognosis. Conclusion the expression of ZNF217 is increased in colon cancer tissues, and it can be used as an independent potential molecular marker to judge the survival and prognosis of colon cancer patients.
【作者單位】： 湖北醫(yī)藥學(xué)院附屬東風(fēng)總醫(yī)院消化內(nèi)科;
【分類號(hào)】：R735.35

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