本文選題：甲狀腺乳頭狀癌 + 濾泡亞型　； 參考：《山西醫(yī)科大學(xué)》2015年碩士論文

【摘要】：目的:分析甲狀腺乳頭狀癌濾泡亞型(Follicular Variant of Papillary Thyroid Carcinoma,FVPTC)的臨床病理特點(diǎn)。探討其與經(jīng)典甲狀腺乳頭狀癌(Classical Papillary Thyroid Carcinoma,CPTC)的臨床病理特征的差異。方法:收集北京協(xié)和醫(yī)院2009年1月到2014年6月297例甲狀腺乳頭狀癌患者的臨床病理資料,由2名病理科醫(yī)生重新進(jìn)行病理診斷并進(jìn)行甲狀腺乳頭狀癌的亞型分類;總結(jié)FVPTC的臨床病理特點(diǎn),并比較其與CPTC的臨床病理特征的差別,同時比較FVPTC中包膜亞型和非包膜亞型之間臨床病理特征的差別。結(jié)果:在297例甲狀腺乳頭狀癌患者中,CPTC 148例,FVPTC 149例,分別占全部甲狀腺乳頭狀癌的49.8%、50.2%;女性患者比例分別65.5%、79.2%,平均年齡為43.17±11.77歲、44.9±9.75歲;在149例FVPTC中,包膜型17例、非包膜型132例,分別占11.4%、88.6%,女性患者比例分別為64.7%、81.1%,平均年齡分別為:45.18±7.41歲、44.86±10.03歲。與CPTC相比,FVPTC在女性患者比例(79.2%vs 65.5%,P=0.008),微小癌比例(77.2%vs 62.8%,P=0.007)、淋巴轉(zhuǎn)移率(43.0%vs 58.8%,P=0.006)、Braf基因突變率(76.2%vs 97.6%,P=0.004)方面存在顯著性差異;在包膜型和非包膜型FVPTC的比較中發(fā)現(xiàn):超聲中惡性病灶邊界不清(53.3%vs 79.1%,P=0.048)和聲暈比例(33.3%vs 3.1%,P=0.001)兩組存在顯著性差異;在CPTC和非包膜型FVPTC的比較中發(fā)現(xiàn):女性患者比例(65.5%vs 81.1%,P=0.004)、微小癌灶比例(62.8%vs 77.3%,P=0.009)、淋巴轉(zhuǎn)移率(58.8%vs 42.4%,P=0.006)以及Braf基因突變率(97.6%vs76.3%,P=0.011)上存在顯著性差異。結(jié)論:FVPTC是很常見的甲狀腺乳頭狀癌的亞型,其有較獨(dú)特的臨床病理特點(diǎn),較CPTC它的淋巴結(jié)轉(zhuǎn)移率、Braf突變率均較低。
[Abstract]:Objective: to analyze the clinicopathological features of follicular variant of papillary thyroid carcinoma (FVPTC). To investigate the difference of clinicopathological features between classical papillary thyroid carcinoma (CPTC) and classical papillary thyroid carcinoma (CPTC). Methods: the clinicopathological data of 297 patients with thyroid papillary carcinoma from January 2009 to June 2014 in Peking Union Hospital were collected. The pathological diagnosis was performed by two pathologists and the subtypes of thyroid papillary carcinoma were classified. To summarize the clinicopathological characteristics of FVPTC, and to compare the differences between FVPTC and CPTC in clinicopathological features, and the differences of clinicopathological characteristics between the capsule subtypes and non-capsular subtypes in FVPTC. Results: of 297 patients with papillary thyroid carcinoma, 149 were CPTC with FVPTC, accounting for 49.8% of all papillary thyroid carcinomas, 79.2% of female patients, with an average age of 43.17 鹵11.77 years (44.9 鹵9.75 years), and 17 cases of capsular type and 132 cases of non-capsular type in 149 cases of FVPTC. The proportion of female patients was 64.7 and 81.1, the average age was 45.18 鹵7.41 years old and 44.86 鹵10.03 years old, respectively. Compared with CPTC, there were significant differences in the proportion of female patients (79.2%vs 65.5i), 77.2%vs (77.2%vs 62.8and P0. 007), lymphatic metastasis rate (43.0%vs 58.8 P0. 006) and 76.2%vs 97. 6% (P0.004). In the comparison of the envelope type and the non-encapsulated type, it was found that there were significant differences between the two groups: the boundary of malignant lesions was unclear (53.3%vs 79.1) and the ratio of acoustical halo (33.3%vs 3.1) was significantly different between the two groups. It was found that there were significant differences in the percentage of female patients (65.5%vs 81.1), the proportion of small cancer foci (62.8%vs 77.3P + P0. 009), lymphatic metastasis rate (58.8%vs 42.4G), and Braf gene mutation rate (97.6vs76.3P0. 011) between CPTC and non-encapsulated FVPTC. Conclusion FVPTC is a very common subtype of papillary thyroid carcinoma, which has unique clinicopathological characteristics and has lower lymph node metastasis rate and Braf mutation rate than CPTC.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R736.1

【參考文獻(xiàn)】

相關(guān)碩士學(xué)位論文 前1條

1 盧燕紅;甲狀腺乳頭狀癌幾種罕（少）見侵襲性變異型[D];蚌埠醫(yī)學(xué)院;2014年

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