本文選題：生命質(zhì)量 + 頭頸癌��； 參考：《昆明醫(yī)科大學(xué)》2017年碩士論文

【摘要】：[目的]研制癌癥患者生命質(zhì)量測定量表體系之頭頸癌量表(The Quality of Life Instrument for Head and neck cancer,QLICP-HN)(V2.0T)以及歐洲癌癥研究和治療組織的EORTC生命質(zhì)量測定量表QLQ-C30QLQ-HN35中文版量表,分別考評并比較兩個(gè)量表。[方法]依據(jù)共性模塊與特異模塊相結(jié)合的研究思想,通過大量回顧國內(nèi)外相關(guān)文獻(xiàn)資料,結(jié)合國內(nèi)外文化特點(diǎn),以開發(fā)量表的程序化決策方式研制QLICP-HN量表,主要包括:訪談、小組集中討論、統(tǒng)計(jì)分析結(jié)合臨床實(shí)際等。同時(shí)通過量表漢化的一系列包括翻譯、回譯、文化調(diào)試等步驟研制QLQ-HN35中文版,再同已有的QLQ-C30中文版結(jié)合形成QLQ-C30QLQ-HN35中文版量表。采用兩個(gè)量表在入院時(shí)對100例頭頸癌患者進(jìn)行第一次測試,并在患者入院2～3天進(jìn)行第二次量表測試;在患者出院時(shí)進(jìn)行第三次量表測試,通過最終的調(diào)查數(shù)據(jù)來考評兩個(gè)量表的測量學(xué)特性(信度、效度、反應(yīng)度),同時(shí)對兩個(gè)量表進(jìn)行比較。在處理數(shù)據(jù)分析時(shí)采用的統(tǒng)計(jì)學(xué)方法有:統(tǒng)計(jì)描述、配對t檢驗(yàn)、相關(guān)性分析、探索性因子分析等。[結(jié)果]1.研制出了含16個(gè)條目的頭頸癌特異模塊,與已有含39個(gè)條目的共性模塊QLICP-GM結(jié)合形成頭頸癌患者生命質(zhì)量量表QLICP-HN;同時(shí),還研制出了 EORTCQLQ-C30QLQ-HN35 中文版量表。2.對QLICP-HN量表進(jìn)行考評,結(jié)果顯示該量表的重測信度為0.990,克朗巴赫系數(shù)為0.646,分半信度為0.673。相關(guān)分析和因子分析顯示QLICP-HN量表的結(jié)構(gòu)效度尚可,采用QLQ-C30QLQ-HN35中文版量表作為效標(biāo)分析可知,r=0.756(P0.001),所以頭頸癌患者生命質(zhì)量測定量表與效標(biāo)測定量表有較高的相關(guān)性,可以認(rèn)為具有較好的效標(biāo)效度。3.對QLQ-C30QLQ-HN35中文版量表進(jìn)行考評,并將QLICP-HN量表與QLQ-C30QLQ-HN35中文版量表進(jìn)行比較:從內(nèi)容上看,兩量表均能反映生命質(zhì)量測量的基本內(nèi)容,但存在異同點(diǎn);從測量學(xué)特性上看,兩量表的效度、反應(yīng)度均較好,信度尚可,其中結(jié)構(gòu)效度、反應(yīng)度接近,且均具有較好的內(nèi)容效度。[結(jié)論]頭頸癌患者生命質(zhì)量量表QLICP-HN有良好的效度、反應(yīng)度,信度尚可,可用于中國頭頸癌患者生命質(zhì)量的測評。QLICP-HN量表與QLQ-C30QLQ-HN35中文版量表比較,內(nèi)容上存在異同點(diǎn);測量學(xué)特征上兩量表類似。
[Abstract]:[objective] to develop the quality of Life instrument for head and neck Cancer scale (QLLICP-HNU V2.0T) and the quality of Life scale (QLQ-C30QLQQ-H35) of European Organization for Research and treatment of Cancer. The two scales were evaluated and compared. [methods] the QLICP-HN scale was developed according to the research idea of combining the common module with the specific module, by reviewing a large number of domestic and foreign literature, combining with the characteristics of domestic and foreign culture, and developing the QLICP-HN scale by the way of programmed decision making of developing the scale, which mainly included: interview, etc. Group discussion, statistical analysis combined with clinical practice and so on. At the same time, the Chinese version of QLQ-HN35 was developed through a series of Chinese version of the scale, including translation, back translation and cultural debugging, and the QLQ-C30QLQ-HN35 Chinese version was formed by combining with the existing QLQ-C30 Chinese version. 100 patients with head and neck cancer were tested for the first time at admission with two scales, and the second scale was tested on the 2nd day after admission, and the third time when the patient was discharged from hospital. The measurement characteristics (reliability, validity, response) of the two scales were evaluated by the final survey data, and the two scales were compared. The statistical methods used in data analysis are: statistical description, paired t test, correlation analysis, exploratory factor analysis and so on. [result] 1. A specific model of head and neck cancer with 16 items was developed, which combined with the common module QLICP-GM with 39 items to form QLICP-HN.The EORTCQLQ-C30QLQ-HN35 Chinese version of QLICP-HN35 was also developed. The QLICP-HN scale was evaluated. The results showed that the test-retest reliability of QLICP-HN was 0.990, the Cronbach coefficient was 0.646, and the split-half reliability was 0.673. Correlation analysis and factor analysis showed that the structure validity of QLICP-HN scale was fairly good. The QLQ-C30QLQ-HN35 Chinese version scale was used to analyze the validity of QLICP-HN scale. The QLQ-C30QLQ-HN35 scale was used to analyze the validity of QLICP-HN scale. Therefore, there was a high correlation between QLICP-HN scale and QLQ-C30QQ-HN35 scale. It can be considered that it has good standard validity. 3. The Chinese version of QLQ-C30QLQ-HN35 was evaluated, and the QLICP-HN scale was compared with QLQ-C30QLQQ-HN35. Among them, the structure validity and the reaction degree were close, and all had good content validity. [conclusion] QLICP-HN has good validity, response and reliability. It can be used to evaluate QLICP-HN and QLQ-C30QLQQ-HN35 in China. There are some similarities and differences between QLICP-HN and QLQ-C30QLQ-HN35. The characteristics of the two scales are similar.
【學(xué)位授予單位】：昆明醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R739.91

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