本文選題：痰熱清注射液 + 合并慢性阻塞性肺疾病肺癌��； 參考：《中國老年學雜志》2017年24期

【摘要】：目的探討痰熱清能否減輕合并慢性阻塞性肺疾病(COPD)肺癌患者術后炎癥反應和肺損傷的程度。方法選擇39例合并COPD肺癌患者(痰熱瘀肺型)隨機分為被試組18例和對照組21例。所有患者行胸腔鏡輔助下小切口手術。對照組用西醫(yī)常規(guī)治療,被試組加用痰熱清注射液。在術前1 d(T_1)、術后第1天(T_2)、第3天(T_3)、第7天(T_4)采集血清標本,測定兩組血清腫瘤壞死因子(TNF)-α、白細胞介素(IL)-6、IL-8和IL-10濃度。結果在T_1、T_2時間點,兩組TNF-α、IL-6、IL-8和IL-10水平無顯著差異(P0.05);在T_3時間點,被試組TNF-α、IL-6和IL-8水平明顯低于對照組(P0.05),IL-10水平明顯高于對照組(P0.05);在T_4時間點,被試組TNF-α、IL-6和IL-8水平明顯低于對照組(P0.05),兩組T_3、T_4時間點TNF-α、IL-6、IL-8水平均較T_2時間點顯著降低(P0.05),T_2、T_3時間點IL-10逐漸上升,均明顯高于T1時間點(P0.05)。結論痰熱清注射液能減少合并COPD肺癌圍術期間炎癥因子的釋放,增加抗炎癥因子生成,從而減輕炎癥反應程度,減輕肺臟損傷,保護肺功能。
[Abstract]:Objective to investigate whether Tanreqing can alleviate the postoperative inflammatory reaction and lung injury in patients with chronic obstructive pulmonary disease (COPD). Methods 39 patients with COPD lung cancer (phlegm heat stasis lung type) were randomly divided into two groups: the control group (n = 21) and the control group (n = 18). All patients underwent thoracoscopic assisted small incision surgery. The control group was treated with routine western medicine, and the test group was treated with Tanreqing injection. Serum levels of TNF- 偽, IL-IL-6, IL-8 and IL-10 were measured on the first day before operation, on the first day after operation, on the third day after operation, on the seventh day, and on the seventh day, the serum samples were collected and the levels of TNF- 偽, IL-8 and IL-10 were measured. Results there was no significant difference in the levels of IL-8 and IL-10 between the two groups at the time point of T _ 1 / T _ 2. At the time point of T3, the levels of TNF- 偽 IL-6 and IL-8 in the subjects group were significantly lower than those in the control group (P 0.05), and the levels of IL-10 in the control group were significantly higher than those in the control group (P 0.05), and at the T4 time point, the levels of TNF- 偽, IL-6 and IL-8 were significantly higher than those in the control group. The levels of TNF- 偽 IL-6 and IL-8 in the subjects group were significantly lower than those in the control group (P 0.05), and the levels of TNF- 偽 IL-6 and IL-8 in the two groups were significantly lower than those in the T _ 2 / T _ 2 group, which were significantly higher than those in the T _ 1 / T _ 1 group. Conclusion Tanreqing injection can reduce the release of inflammatory factors and increase the production of anti-inflammatory factors during perioperative period of lung cancer with COPD, so as to reduce the degree of inflammatory reaction, reduce lung injury and protect lung function.
【作者單位】： 江西中醫(yī)藥大學附屬醫(yī)院;南昌市中西醫(yī)結合醫(yī)院;
【基金】：江西省衛(wèi)生計生委中醫(yī)藥科研計劃(No.2013B033)
【分類號】：R563.9;R734.2

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