本文選題：血清糖類抗原 + 糖蛋白抗原(CA)-��； 參考：《中國老年學(xué)雜志》2017年24期

【摘要】：目的探討血清糖蛋白抗原(CA)19-9與CA24-2水平動(dòng)態(tài)表達(dá)在老年膽管細(xì)胞癌患者診斷、預(yù)后及復(fù)發(fā)中的臨床意義。方法采用電化學(xué)發(fā)光免疫分析法,分別以年齡匹配的20例膽系良性疾病及20例正常人作對(duì)照,對(duì)26例老年膽管細(xì)胞癌患者外周血CA19-9與CA24-2水平進(jìn)行檢測(cè)。結(jié)果膽管細(xì)胞癌組外周血CA19-9與CA24-2表達(dá)陽性率分別為76.9%,69.2%,明顯高于膽系良性疾病組(5.0%,10.0%)及正常對(duì)照組(0.0%,5.0%)(均P0.01);CA19-9、CA24-2的均值分別[(1 571.82±291.75)、(181.69±71.80)U/ml]明顯高于膽系良性疾病組[(28.52±10.61)、(16.26±11.50)U/ml]及正常對(duì)照組[(22.53±6.42)、(10.68±5.87)U/ml](P0.01)。CA19-9與CA24-2聯(lián)合檢測(cè)陽性率(88.5%)明顯高于單一檢測(cè)(P0.05)。臨床影像學(xué)檢查提示膽管細(xì)胞癌占位性病變的,同時(shí)CA19-9、CA24-2聯(lián)合檢測(cè)明顯升高的患者術(shù)后經(jīng)病理證實(shí)均為膽管細(xì)胞癌。未復(fù)發(fā)膽管細(xì)胞癌組術(shù)后1 w CA19-9、CA24-2水平較術(shù)前均明顯下降(P0.05);而術(shù)后復(fù)發(fā)組術(shù)后1 w血清CA19-9、CA24-2較術(shù)前亦明顯下降(P0.05);術(shù)后4 w下降最明顯,術(shù)后12 w水平回升;姑息手術(shù)組手術(shù)前后CA19-9、CA24-2水平無顯著變化(P0.05)。結(jié)論動(dòng)態(tài)監(jiān)測(cè)血清CA19-9、CA24-2水平變化對(duì)于老年膽管細(xì)胞癌的臨床診斷及術(shù)后復(fù)發(fā)的判斷均有重要價(jià)值。
[Abstract]:Objective to investigate the clinical significance of dynamic expression of serum glycoprotein antigen CA19 9 and CA24-2 in the diagnosis, prognosis and recurrence of cholangiocarcinoma in elderly patients. Methods the levels of CA19-9 and CA24-2 in peripheral blood of 26 elderly patients with cholangiocarcinoma were detected by electrochemiluminescence immunoassay (ECL) with 20 age-matched benign biliary diseases and 20 normal controls. 緇撴灉鑳嗙緇嗚優(yōu)鐧岀粍澶栧懆琛，

本文編號(hào)：1976114