本文選題：宮頸微偏腺癌 + 粘蛋白2��； 參考：《南華大學(xué)》2016年碩士論文

【摘要】：目的:檢測宮頸微偏腺癌(MDA)中MUC2、MUC6、KI67蛋白的表達(dá)情況,探討其在MDA發(fā)生發(fā)展中的可能意義,為MDA的早期診斷、鑒別診斷、治療及預(yù)后提供一定的客觀依據(jù)。方法:采用免疫組化SP法檢測15例正常宮頸,15例非典型增生腺體,20例普通腺癌,20例宮頸微偏腺癌組織中的MUC2、MUC6、KI67蛋白的表達(dá)。應(yīng)用SPSS18.0統(tǒng)計軟件進(jìn)行數(shù)據(jù)分析,檢驗水準(zhǔn),α=0.05。結(jié)果:1.Ki-67蛋白的陽性表達(dá)率在正常宮頸腺上皮組織(6.7%)、宮頸腺上皮不典型增生(20%)、普通宮頸腺癌(50%)及宮頸微偏腺癌(90%),呈上升趨勢,四組比較差異均具有顯著性(P0.05)2.MUC2蛋白的陽性表達(dá)率在正常宮頸腺上皮組織(13.3%)、宮頸腺上皮不典型增生(26.7%)、普通宮頸腺癌(55%)及宮頸微偏腺癌(85%),呈上升趨勢,四組比較差異均具有顯著性(P0.05)3.MUC6蛋白的陽性表達(dá)率在正常宮頸腺上皮組織(13.3%)、宮頸腺上皮不典型增生(33.3%)、普通宮頸腺癌(60%)及宮頸微偏腺癌(75%),呈上升趨勢,四組比較差異均具有顯著性(P0.05)4.Ki-67蛋白的陽性表達(dá)率在宮頸MDA組(90%)與普通宮頸腺癌組(50%)中,差異具有統(tǒng)計學(xué)意義(P0.05)。5.MUC2蛋白的陽性表達(dá)率在宮頸MDA組(85%)與普通宮頸腺癌組(55%)中,差異具有統(tǒng)計學(xué)意義(P0.05)。結(jié)論:1.Ki-67、MUC2、MUC6蛋白的陽性表達(dá)率在正常宮頸腺體、宮頸腺體不典型增生中呈上升趨勢,可能其與MDA的發(fā)生發(fā)展有關(guān),與MDA的惡性程度有關(guān)。2.Ki-67蛋白、MUC2蛋白在MDA的陽性表達(dá)率顯著高于普通宮頸腺癌,提示其有助于MDA的鑒別診斷。
[Abstract]:Objective: to detect the expression of MUC2Muc6KI67 protein in cervical carcinoma of the cervix, and to explore its possible significance in the pathogenesis and development of MDA, and to provide an objective basis for the early diagnosis, differential diagnosis, treatment and prognosis of MDA. Methods: immunohistochemical SP method was used to detect the expression of MUC2 muc6pKI67 protein in 15 cases of normal cervical carcinoma (n = 15) and 20 cases of normal adenocarcinoma (n = 20). SPSS18.0 statistical software for data analysis, test level, a 0. 05. Results 1. The positive expression rate of Ki-67 protein in normal epithelium of cervix glandular epithelium, atypical hyperplasia of glandular epithelium of cervix and normal cervical adenocarcinoma was 6.7. There were significant differences among the four groups in the positive expression rate of P0.05m2.MUC2 protein in normal cervical gland epithelium, atypical hyperplasia of cervical gland epithelium and normal cervical adenocarcinoma (5555C), and the positive rate of MUC2 protein in normal cervix glandular epithelium was on the rise, and there was an increasing trend in the expression of MUC2 protein in normal cervix glandular epithelium and normal adenocarcinoma of cervix. The positive expression rate of MUC6 protein was significantly higher in normal cervical gland epithelium than in normal cervix epithelium, cervical epithelial dysplasia, normal cervical adenocarcinoma and normal cervical adenocarcinoma. The positive expression rate of MUC6 protein in all the four groups was significantly higher than that in normal cervical gland epithelium, and in normal cervical adenocarcinoma, the positive expression rate of MUC6 protein was significantly higher than that in normal cervical gland epithelium. The positive expression rate of Ki-67 protein in cervical MDA group was significantly higher than that in normal cervical adenocarcinoma group (P 0.05). The positive expression rate of Ki-67 protein in cervical MDA group was significantly higher than that in normal cervical adenocarcinoma group (P 0.05) and normal cervical adenocarcinoma group (5555). The difference was statistically significant (P 0.05). Conclusion: 1. The positive expression rate of MUC6 protein in normal cervical gland and atypical hyperplasia of cervical gland is increasing, which may be related to the occurrence and development of MDA. The positive expression rate of MUC2 protein in MDA was significantly higher than that in normal cervical adenocarcinoma, suggesting that it was helpful for differential diagnosis of MDA.
【學(xué)位授予單位】：南華大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R737.33

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 田芳;周慶云;王sピ，

本文編號：1942930