本文選題：腫瘤 + 有限元��； 參考：《南京航空航天大學》2017年碩士論文

【摘要】：微創(chuàng)微波熱消融技術具有創(chuàng)傷小、可預測消融范圍大小且療效顯著等特點,廣泛應用于肝癌、腎癌等實體瘤的臨床治療,微波消融治療術前準確有效的手術計劃和術中實時精確療效評估是目前臨床亟待解決的重要問題。針對上述問題,本文通過經(jīng)典的組織熱消融溫度場作為療效評估標準,開展微波熱療的療效評估系統(tǒng)研究,并基于評估模型開發(fā)一套基于CT影像的術前微波消融治療計劃系統(tǒng)。論文主要研究內(nèi)容:1、針對臨床使用的標準微波消融針,采用動態(tài)生物組織參數(shù)的有限元仿真技術,得到準確有效的微波消融仿真模型。用COMSOL將仿真模型打包封裝為界面友好的仿真App,實現(xiàn)不同治療劑量的快速精確仿真;2、利用微波熱療有限元仿真結(jié)果獲得了不同治療劑量的有效熱消融溫度場分布和有效消融體積,建立了組織熱消融溫度場模型。并通過離體豬肝實驗進行實驗驗證,通過消融效果比較,驗證了仿真模型的準確性和有效性;3、為了實現(xiàn)微波熱消融的精準治療,設計了一套微波熱消融軟件系統(tǒng),嵌入了本文研究獲得的溫度場模型。系統(tǒng)軟件基于CT影像開發(fā),能夠?qū)崿F(xiàn)基本的影像導入、3D重建、腫瘤勾畫等功能,并能夠完成術前治療計劃。論文主要創(chuàng)新點:采用隨溫度變化的動態(tài)生物熱物性參數(shù)和電學參數(shù)作為仿真的參數(shù),可以更精準的獲得消融過程中組織溫度場的分布;獲得和臨床應用完全吻合的微波消融針的精準溫度場熱消融模型,直接可以在臨床上使用;一套具備熱消融手術計劃和術中實時療效評估的醫(yī)學影像系統(tǒng)軟件。本文研究結(jié)果對腫瘤微創(chuàng)微波熱療設備的開發(fā)具有重要的意義。
[Abstract]:Minimally invasive microwave thermal ablation is widely used in the treatment of solid tumors such as liver cancer and renal cell carcinoma. Accurate and effective preoperative operation plan and real-time and accurate evaluation of the efficacy of microwave ablation are important problems to be solved in clinical practice. In order to solve the above problems, this paper uses the classical temperature field of tissue thermal ablation as the evaluation standard, and develops a preoperative microwave ablation planning system based on CT images to evaluate the efficacy of microwave hyperthermia. According to the standard microwave ablation needle used in clinic, the finite element simulation technique of dynamic biological tissue parameters is used to obtain an accurate and effective microwave ablation simulation model. The simulation model is packaged into a friendly interface simulation Appwith COMSOL to realize the fast and accurate simulation of different therapeutic doses. The effective thermal ablation temperature field distribution and effective ablation volume of different therapeutic doses are obtained by using the finite element simulation results of microwave hyperthermia. The temperature field model of tissue thermal ablation was established. Through the experiment of pig liver in vitro, the accuracy and validity of the simulation model are verified by the comparison of ablation results. In order to realize the accurate treatment of microwave thermal ablation, a microwave ablation software system is designed. The temperature field model obtained in this paper is embedded. The system software is based on CT image development, which can realize the basic functions of image import 3D reconstruction, tumor drawing and so on, and can complete the preoperative treatment plan. The main innovations of this paper are as follows: the temperature distribution of the tissue can be obtained more accurately by using the dynamic biophysical and electrical parameters as the simulation parameters; An accurate thermal ablation model of microwave ablation needle is obtained, which can be used directly in clinic. A set of medical imaging system software with thermal ablation operation plan and real-time evaluation of therapeutic effect during operation is developed. The results of this study are of great significance to the development of minimally invasive microwave hyperthermia for tumor.
【學位授予單位】：南京航空航天大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：TN015;R730.5

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