本文選題：心電描記術(shù) + 蒽環(huán)類��； 參考：《中國全科醫(yī)學(xué)》2017年09期

【摘要】：目的研究化療期間心電圖異常對(duì)蒽環(huán)類藥物引起乳腺浸潤性導(dǎo)管癌患者慢性心臟毒性的預(yù)測價(jià)值。方法收集鄭州大學(xué)第二附屬醫(yī)院乳腺外科2013年5月—2015年5月收治的經(jīng)病理檢查確診為乳腺浸潤性導(dǎo)管癌患者123例。根據(jù)隨訪期間是否發(fā)生心臟毒性分為心臟毒性組21例和無心臟毒性組102例。觀察兩組心電圖檢查結(jié)果,分析乳腺浸潤性導(dǎo)管癌化療后發(fā)生慢性心臟毒性的影響因素。結(jié)果兩組年齡比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05);心臟毒性組心電圖異常、ST-T段改變、T波異常發(fā)生率高于非心臟毒性組(P0.05);心臟毒性組心電圖異常次數(shù)多于非心臟毒性組(P0.05)。多因素Logistic回歸分析顯示,年齡、心電圖異常次數(shù)、ST-T段改變、T波異常是乳腺浸潤性導(dǎo)管癌化療后慢性心臟毒性的影響因素(P0.05)。結(jié)論女性乳腺浸潤性導(dǎo)管癌的年齡、化療期間心電圖異常與慢性心臟毒性發(fā)生有一定相關(guān)性,對(duì)早期預(yù)防和治療化療引起的慢性心臟毒性有重要的臨床指導(dǎo)意義。
[Abstract]:Objective to study the predictive value of abnormal ECG during chemotherapy for chronic cardiac toxicity in patients with invasive ductal carcinoma of breast induced by anthracyclines. Methods 123 patients with invasive ductal carcinoma of breast diagnosed by pathological examination from May 2013 to May 2015 in the second affiliated Hospital of Zhengzhou University were collected. According to whether or not cardiac toxicity occurred during follow-up period, 21 patients were divided into two groups: cardiac toxicity group (n = 21) and no cardiac toxicity group (n = 102). The results of electrocardiogram (ECG) in two groups were observed and the influencing factors of chronic cardiac toxicity after chemotherapy for invasive ductal carcinoma of breast were analyzed. Results there was significant difference between the two groups in age, the incidence of abnormal T wave in ECG abnormal ST-T segment in cardiotoxicity group was higher than that in non-cardiotoxic group, and the frequency of abnormal ECG in cardiotoxicity group was more than that in non-cardiotoxic group. Multivariate Logistic regression analysis showed that age and abnormal frequency of electrocardiogram (ECG) and abnormal ST-T segment were the influencing factors of chronic cardiotoxicity after chemotherapy for invasive ductal carcinoma of breast (P 0.05). Conclusion the age of female breast invasive ductal carcinoma, the abnormal ECG during chemotherapy and the occurrence of chronic cardiac toxicity are related to the occurrence of chronic cardiac toxicity, which has important clinical significance for early prevention and treatment of chronic cardiac toxicity caused by chemotherapy.
【作者單位】： 鄭州大學(xué)第二附屬醫(yī)院乳腺外科;
【分類號(hào)】：R737.9

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本文編號(hào)：1933369