本文選題：乳腺腫瘤 + 病理學(xué)��； 參考：《中華疾病控制雜志》2017年05期

【摘要】：目的比較家族性乳腺癌和散發(fā)性乳腺癌患者的臨床病理特征,揭示家族性乳腺癌獨特的臨床病理學(xué)及分子生物學(xué)特性。方法回顧性分析廣西醫(yī)科大學(xué)第一附屬醫(yī)院胃腸腺體外科2013年1月~2014年1月期間收治中的445例女性乳腺癌患者臨床病理資料,其中家族性乳腺癌患者43例,散發(fā)性乳腺癌402例。比較分析兩組臨床病理特征、分子生物學(xué)行為以及復(fù)發(fā)、轉(zhuǎn)移等情況。結(jié)果在組織學(xué)分級中家族性乳腺癌患者分為III級所占的比例(37.2%)高于散發(fā)性乳腺癌患者所占的比例(22.6%),差異有統(tǒng)計學(xué)意義(X~2=4.517,P=0.034);家族性乳腺癌患者的雌激素受體(estrogen receptor,ER)表達陰性率(39.5%)高于散發(fā)性乳腺癌患者(25.4%),差異有統(tǒng)計學(xué)意義(X~2=3.977,P=0.046);Kaplan-Meier生存分析顯示:家族性乳腺癌組3年無病生存率(disease free survival,DFS)為86.0%,而散發(fā)性組3年無病生存率為95.5%,差異有統(tǒng)計學(xué)意義(X~2=7.371,P=0.007)。但兩組患者在年齡分布、民族、體質(zhì)指數(shù)(body mass index,BMI)、絕經(jīng)狀態(tài)、腫瘤大小、病理類型、臨床分期、腋窩淋巴結(jié)轉(zhuǎn)移率、孕激素受體(progestrone receptor,PR)、人類表皮生長因子受體-2(human epidermal growth factor receptor-2,HER-2)、細胞核增殖抗原(cell nucleus generation antigen,Ki-67)表達以及乳腺癌分子分型方面差異均無統(tǒng)計學(xué)意義(均有P0.05)。結(jié)論廣西地區(qū)家族性乳腺癌與散發(fā)性乳腺癌在一些臨床病理特征上存在差異,可能提示預(yù)后不良。
[Abstract]:Objective to compare the clinicopathological characteristics of familial breast cancer and sporadic breast cancer, and to reveal the unique clinicopathological and molecular biological characteristics of familial breast cancer. Methods Clinical and pathological data of 445 female breast cancer patients treated in the first affiliated Hospital of Guangxi Medical University from January 2013 to January 2014 were analyzed retrospectively. 43 cases of familial breast cancer and 402 cases of sporadic breast cancer were analyzed. The clinicopathological characteristics, molecular biological behavior, recurrence and metastasis were compared between the two groups. Results in histological grade, the proportion of familial breast cancer patients divided into III grade (37.2g) was higher than that of sporadic breast cancer patients (22.6g%), the difference was statistically significant (P < 0.05); estrogen receptor (ER) expression in familial breast cancer patients was significantly higher than that in sporadic breast cancer patients (P < 0.05). The negative rate (39.5%) was higher than that in sporadic breast cancer patients (25.44%). The difference was statistically significant. Kaplan-Meier survival analysis showed that the 3-year disease-free survival rate of familial breast cancer group was 86.0 and that of sporadic group was 95.55.The difference was statistically significant. But in age distribution, nationality, body mass index (BMI) mass BMIA, menopausal status, tumor size, pathological type, clinical stage, axillary lymph node metastasis rate, There were no significant differences in the expression of progestrone receptor, human epidermal growth factor receptor -2human epidermal growth factor receptor-2hER-2and proliferating cell nucleus generation antigen-Ki-67 (all P 0.05). Conclusion there are some differences in clinicopathological features between familial breast cancer and sporadic breast cancer in Guangxi, which may indicate poor prognosis.
【作者單位】： 廣西醫(yī)科大學(xué)第一附屬醫(yī)院胃腸腺體外科;合肥市第二人民醫(yī)院內(nèi)科;廣西醫(yī)科大學(xué)第一附屬醫(yī)院外科;
【基金】：廣西醫(yī)療衛(wèi)生適宜技術(shù)研究與開發(fā)課題資助項目(S201415-03)
【分類號】：R737.9

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