本文選題：血清硒 + 肺癌　； 參考：《吉林大學(xué)》2017年碩士論文

【摘要】：目的:有研究表明微量元素硒與肺癌的發(fā)生、發(fā)展及預(yù)后具有密切聯(lián)系,但也有研究發(fā)現(xiàn),微量元素硒與肺癌的發(fā)病并無明顯關(guān)系。本研究擬探討血清硒水平與肺癌發(fā)病的相關(guān)性。方法:1.回顧性分析2011年1月1日至2015年12月31日期間,就診于吉林大學(xué)第一醫(yī)院的147例肺癌患者及149例同期健康門診體檢者。其中男性140例(47.3%),女性156例(52.7%);男女比例為0.90:1,年齡最小者為23歲,最大者為86歲。2.所有血清標(biāo)本統(tǒng)一于空腹時采集,并迅速避光保護(hù)并分離血清,置于我院-70℃標(biāo)本儲存庫內(nèi)密封冷凍保存。應(yīng)用電感耦合等離子體質(zhì)譜法(ICP-MS)進(jìn)行血清中硒濃度的檢測,并收集患者臨床資料信息。3.應(yīng)用t檢驗及卡方檢驗分析一般臨床資料分布特點。采用卡方檢驗及Logistic多因素回歸分析法等,分析人體血清硒水平與肺癌風(fēng)險的相關(guān)性。通過ROC曲線找到診斷截點,對肺癌發(fā)病風(fēng)險進(jìn)行預(yù)測。結(jié)果:1.單因素分析表明,低血清硒水平、吸煙、有肺癌家族史是肺癌發(fā)病的危險因素。2.Logistic多因素分析顯示,低血清硒水平、吸煙、肺癌家族史是肺癌發(fā)病的危險因素。其中,低血清硒(80.67μg/L)者肺癌發(fā)生的風(fēng)險是高血清硒(≥80.67μg/L)者的2.66倍(95%CI:1.47-4.81)。3.綜合吸煙、性別、年齡、肺癌家族史等因素,將血清硒水平與疾病診斷繪制ROC曲線,結(jié)果顯示ROC曲線下面積為0.820,(95%CI:0.773-0.867)。ROC曲線下面積在0.7-0.9之間表示診斷價值中等。4.血清硒水平在肺癌不同分期中無統(tǒng)計學(xué)意義(P0.05)。結(jié)論:1.血清硒水平降低是肺癌發(fā)病的獨立危險因素。2.綜合吸煙、性別、年齡、肺癌家族史等因素,血清硒水平對肺癌的診斷具有中等診斷價值。
[Abstract]:Objective: some studies have shown that trace element selenium is closely related to the occurrence, development and prognosis of lung cancer, but there is no obvious relationship between trace element selenium and lung cancer. The aim of this study was to investigate the correlation between serum selenium level and lung cancer. Method 1: 1. During the period from January 1, 2011 to December 31, 2015, 147 patients with lung cancer and 149 health outpatients who were admitted to the first Hospital of Jilin University were analyzed retrospectively. The ratio of male to female is 0.90: 1, the youngest is 23 years old, the oldest is 86 years old. All serum samples were collected on an empty stomach. The serum was quickly protected by light and separated. The serum was stored at -70 鈩，

本文編號：1895664