發(fā)布時間：2018-05-05 13:04

  本文選題：結直腸癌 + FOXP1��； 參考：《山西醫(yī)科大學》2017年碩士論文

【摘要】：目的:通過研究叉頭框P1(forkhead box P1,FOXP1)及白介素-6(Interleukin-6,IL-6)在人結直腸腺癌組織中的表達及其與臨床病理學參數間的關系,探討二者在結直腸腺癌中的作用及二者間的相關性。方法:采用免疫組化法檢測120例結直腸腺癌組織及20例癌旁組織中FOXP1及IL-6的表達,分析各指標與結直腸腺癌臨床病理學參數間關系及FOXP1與IL-6的相關性。結果:(1)結直腸腺癌組織中FOXP1及IL-6的陽性表達率分別為68.3%和75.8%,癌旁組織中FOXP1及IL-6的陽性表達率分別為35%和20.0%。與癌旁組織相比,FOXP1及IL-6在結直腸腺癌組織中的表達明顯增加。(2)FOXP1在高、中、低分化組中的表達率分別為:36.0%、69.4%、90.9%,隨著分化程度下降,表達依次增加,χ2=19.881,p0.01;FOXP1在有淋巴結轉移組中的表達率為80.9%,與無淋巴結轉移組(30.8%)相比表達明顯升高,χ2=24.325,p0.01;FOXP1在Ⅰ+Ⅱ期表達率為51.8%,明顯低于Ⅲ+Ⅳ期表達率76.6%,χ2=8.059,p=0.007。FOXP1在結直腸腺癌中的表達增加與患者年齡、性別、發(fā)生部位差異無統計學意義(p0.05)。(3)IL-6在高、中、低分化組中的表達率分別為:64.0%、70.9%、93.9%,隨著分化程度下降,表達依次增加,χ2=8.614,p=0.013;IL-6在淋巴結轉移組中的表達率為81.9%,明顯高于無淋巴結轉移組53.8%,χ2=19.875,p0.01;IL-6在Ⅰ+Ⅱ期表達率為64.3%,Ⅲ+Ⅳ期與之相比,表達率(85.9%)顯著增加,χ2=7.640,p=0.01。IL-6在結直腸腺癌中的表達增加與患者年齡、性別、發(fā)生部位無明顯統計學差異(p0.05)。(4)FOXP1與IL-6蛋白表達呈正相關關系(r=0.453,p0.01)。結論:(1)FOXP1及IL-6的高表達可能是結直腸腺癌的促進因素。(2)FOXP1及IL-6高表達與結直腸癌的進展、分化程度及淋巴結轉移相關,可能作為結直腸腺癌的有效預后標記物及臨床治療的靶點。(3)FOXP1與IL-6的表達呈現正相關。
[Abstract]:Objective: to investigate the expression of P1(forkhead box P1FXP1 and Interleukin-6IL-6 in human colorectal adenocarcinoma and their relationship with clinicopathological parameters, and to explore their roles in colorectal adenocarcinoma and the correlation between them. Methods: immunohistochemical method was used to detect the expression of FOXP1 and IL-6 in 120 cases of colorectal adenocarcinoma and 20 cases of paracancerous tissues. The relationship between each index and clinicopathological parameters of colorectal adenocarcinoma and the correlation between FOXP1 and IL-6 were analyzed. Results the positive expression rates of FOXP1 and IL-6 in colorectal adenocarcinoma tissues were 68.3% and 75.8%, respectively. The positive rates of FOXP1 and IL-6 in adjacent tissues were 35% and 20.0%, respectively. The expression rates of FOXP1 and IL-6 in colorectal adenocarcinoma tissues were significantly higher than those in paracancerous tissues. The expression rates of FOXP1 in high, middle and low differentiation groups were 36.0 and 69.4%, respectively, and decreased with the degree of differentiation. The expression of FOXP1 in the group with lymph node metastasis was 80.9, which was significantly higher than that in the group without lymph node metastasis. The expression rate of FOXP1 in stage 鈪，

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