本文選題：乳腺腫瘤 + 鈣化��； 參考：《新疆醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:探討乳腺浸潤性導(dǎo)管癌中鈣化的臨床病理特征及預(yù)后的影響因素。方法:回顧性收集2012年6月-2013年6月在新疆腫瘤醫(yī)院乳腺外科收治的初治可行乳腺癌改良根治術(shù)/保乳根治術(shù)/單純切除術(shù)的307例女性乳腺癌患者的臨床病理資料及隨訪資料,根據(jù)乳腺X線圖像特征分為鈣化組與非鈣化組,采用χ2檢驗(yàn)分析其臨床病理特征之間的差異,逐步Logistic回歸分析影響鈣化存在的相關(guān)因素,運(yùn)用Kaplan-Meier生存分析方法分析鈣化的表達(dá)與患者生存之間的關(guān)系。結(jié)果:(1)鈣化組在病理類型,淋巴結(jié)轉(zhuǎn)移,人表皮生長因子受體2(Her-2)過表達(dá),組織學(xué)分級,臨床分期、分子分型、Ki67與非鈣化組比較差異有統(tǒng)計(jì)學(xué)意義(χ2=21.551、8.480、10.558、6.283、9.682、16.380、3.947,P=0.000、0.037、0.005、0.043、0.021、0.001、0.047)。(2)鈣化是淋巴結(jié)轉(zhuǎn)移及Her-2過表達(dá)的相關(guān)風(fēng)險因素。鈣化組淋巴結(jié)轉(zhuǎn)移的風(fēng)險是非鈣化組的1.736倍;鈣化組Her-2過表達(dá)的風(fēng)險是非鈣化組的2.297倍(P=0.022、0.007,OR=1.736、2.297,95%CI:1.084-2.779、1.260-4.187)。(3)鈣化組和非鈣化組3年無病生存率分別是84.42%和96.15%。對乳腺浸潤性導(dǎo)管癌的預(yù)后行COX多因素分析提示鈣化和淋巴結(jié)狀態(tài)(淋巴結(jié)陽性4-9個和9個)是影響乳腺浸潤性導(dǎo)管癌無病生存時間的獨(dú)立預(yù)后危險因素(P=0.008、0.000(0.021、0.000),95%Cl:1.380-8.510、1.231-12.144和2.570-20.492)。結(jié)論:鈣化是乳腺浸潤性導(dǎo)管癌預(yù)后較差的影響因子。
[Abstract]:Objective: to investigate the clinicopathological features and prognostic factors of calcification in invasive ductal carcinoma of breast. Methods: the clinicopathological data and follow-up data of 307 female breast cancer patients who were treated in breast surgery department of Xinjiang tumor Hospital from June 2012 to June 2013 were retrospectively collected. According to the characteristics of mammogram, the patients were divided into calcified group and non-calcified group. 蠂 2 test was used to analyze the difference between the clinicopathological features and stepwise Logistic regression analysis was used to analyze the related factors affecting the existence of calcification. Kaplan-Meier survival analysis was used to analyze the relationship between calcification expression and patient survival. Results in the calcification group, pathological type, lymph node metastasis, expression of human epidermal growth factor receptor (EGF receptor 2) Her-2), histological grade, and clinical stage were observed. There was significant difference between the molecular typing group and non-calcified group (蠂 ~ 2 + 21.551 ~ 8.480 ~ 10.558 ~ 6.283C ~ (9.682) ~ (16.380) ~ 3.947) calcification was a risk factor of lymph node metastasis and overexpression of Her-2. It was a risk factor of lymph node metastasis and overexpression of Her-2 by 0.037 ~ 0.005 ~ 0. 043 ~ 0. 021 ~ 0. 041 ~ 0. 047. 2) there was a significant difference between the two groups (蠂 ~ (2) ~ (21) 551) and non-calcification (蠂 ~ (2). The risk of lymph node metastasis in the calcified group was 1.736 times higher than that in the non-calcified group, and the risk of Her-2 overexpression in the calcified group was 2.297 times higher than that in the non-calcified group. The 3-year disease-free survival rate was 84.42% in the calcified group and 96.15.1% in the non-calcified group. COX multivariate analysis showed that calcification and lymph node status (positive lymph nodes 4-9 and 9 lymph nodes) were independent prognostic risk factors for the survival time of invasive ductal carcinoma of breast without disease. Conclusion: calcification is a poor prognostic factor in invasive ductal carcinoma of the breast.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R737.9

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