本文選題：胃癌 + 中晚期��； 參考：《中藥材》2017年05期

【摘要】：目的:探討艾迪注射液聯(lián)合SOX方案化療治療中晚期胃癌的療效及對患者生存期、臨床受益的影響。方法:將94例中晚期胃癌患者隨機分為觀察組與對照組各47例。對照組行替吉奧[80 mg/(m~2·d)]+奧沙利鉑[130 mg/m~2]化療(SOX方案),觀察組在對照組基礎(chǔ)上加用艾迪注射液(60~100 m L/天)。觀察比較兩組近期療效、中位疾病進展時間(TTP)、中位生存期(MST),比較兩組患者治療前后臨床受益、腫瘤標志物水平、免疫功能指標及血管內(nèi)皮生長因子(VEGF)水平。結(jié)果:觀察組近期客觀總有效率和疾病控制率分別為55.32%、85.11%,顯著高于對照組的42.55%、72.34%(P0.05);治療后觀察組的癥狀積分、腫瘤標志物(CA125、CA199、CA242、CEA)、免疫功能指標(Treg%、Th17%、Th17/Treg比值)及VEGF水平顯著低于對照組(P0.05),KPS評分及綜合受益率顯著高于對照組(P0.05);觀察組TTP、MST分別為10.45、27.36個月,顯著高于對照組的8.29、20.65個月(P0.05);觀察組的骨髓抑制、胃腸道反應(yīng)及周圍神經(jīng)毒性顯著低于對照組(P0.05)。結(jié)論:艾迪注射液聯(lián)合SOX方案化療治療中晚期胃癌能改善臨床癥狀、延長生存期并提高近期療效,其機制可能與增強免疫和抗VEGF有關(guān)。
[Abstract]:Objective: to investigate the efficacy of Aidi injection combined with SOX regimen in the treatment of advanced gastric cancer and its effect on survival and clinical benefit. Methods: 94 patients with advanced gastric cancer were randomly divided into observation group (n = 47) and control group (n = 47). The control group was given tigueo [80 mg/(m~2 d] oxaliplatin [130 mg/m~2] chemotherapy with Sox regimen, and the observation group was treated with Aidi injection (60 min / L / day) on the basis of the control group. The clinical benefits, tumor markers, immune function and vascular endothelial growth factor (VEGF) were compared between the two groups before and after treatment. Results: the objective total effective rate and disease control rate in the observation group were 55.32 and 85.11, respectively, which were significantly higher than those in the control group (42.55) and 72.34% (P0.05) respectively, the symptom score of the observation group after treatment was significantly higher than that of the control group (P < 0.05). Tumor marker CA125CA199CA242CEA, the ratio of Tregmy Th17 / Th17 / Treg) and VEGF were significantly lower than those of the control group (P0.05) and the comprehensive benefit rate was significantly higher than that of the control group (P 0.05), the TTPMST of the observation group was 10.45,27.36 months, which was significantly higher than that of the control group (8.29, 20.65 months), and the bone marrow depression of the observation group was significantly higher than that of the control group (P 0.05), and the TTPMST of the observation group was significantly higher than that of the control group (P < 0.01). Gastrointestinal reaction and peripheral neurotoxicity were significantly lower than those of control group (P 0.05). Conclusion: Aidi injection combined with SOX regimen can improve the clinical symptoms, prolong the survival time and improve the short-term curative effect of advanced gastric cancer. The mechanism may be related to enhanced immunity and anti-.
【作者單位】： 南京中醫(yī)藥大學(xué);南京中醫(yī)藥大學(xué)附屬醫(yī)院;
【基金】：江蘇省中醫(yī)藥科技項目(YB2015017)
【分類號】：R735.2

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