本文選題：右丙亞胺 + 乳腺癌��； 參考：《中國新藥雜志》2017年11期

【摘要】：目的:對(duì)右丙亞胺預(yù)防乳腺癌患者化療所致心臟毒性的效果和經(jīng)濟(jì)性進(jìn)行系統(tǒng)綜述。方法:計(jì)算機(jī)檢索Pubmed,Science Direct,The Cochrane Library,EMbase,中國知網(wǎng)數(shù)據(jù)庫、萬方數(shù)據(jù)庫和維普中文科技期刊數(shù)據(jù)庫,系統(tǒng)檢索國內(nèi)外公開發(fā)表的蒽環(huán)類藥物聯(lián)用右丙亞胺治療乳腺癌的臨床研究和經(jīng)濟(jì)學(xué)研究,并對(duì)其進(jìn)行質(zhì)量評(píng)價(jià)。結(jié)果:最終納入9篇文獻(xiàn),包含6篇臨床文獻(xiàn)(7項(xiàng)隨機(jī)對(duì)照試驗(yàn))和3篇藥物經(jīng)濟(jì)學(xué)文獻(xiàn)。7項(xiàng)隨機(jī)對(duì)照試驗(yàn)中,聯(lián)用右丙亞胺治療的患者出現(xiàn)心臟毒性和充血性心力衰竭的概率均顯著低于單用蒽環(huán)類藥物的患者。3篇藥物經(jīng)濟(jì)學(xué)研究中,2篇研究顯示相比單用蒽環(huán)類藥物,蒽環(huán)類藥物聯(lián)用右丙亞胺治療乳腺癌具有經(jīng)濟(jì)性,另1篇研究未指出其是否具有經(jīng)濟(jì)性。結(jié)論:右丙亞胺對(duì)于接受蒽環(huán)類藥物化療的乳腺癌患者有顯著的心臟保護(hù)作用。但是,蒽環(huán)類藥物聯(lián)用右丙亞胺治療乳腺癌的藥物經(jīng)濟(jì)學(xué)研究極其有限,需要更多研究來驗(yàn)證。
[Abstract]:Objective: to review the efficacy and economy of dextroimide in preventing cardiotoxicity induced by chemotherapy in breast cancer patients. Methods: computer search was conducted for Pubmedan Science Direct Cochrane Library EMbase, China knowledge Network Database, Wanfang Database and Weipu Chinese Science and Technology Journal Database. The clinical and economic studies of anthracycline combined with dextromine in the treatment of breast cancer at home and abroad were systematically searched and their quality was evaluated. Results: nine articles, including 6 clinical literatures and 7 randomized controlled trials, were included in the study, and 7 randomized controlled trials were included in 3 articles on pharmacoeconomics. The incidence of cardiac toxicity and congestive heart failure in patients treated with dextroimide was significantly lower than that in patients treated with anthracyclines alone. Conclusion: dextroimide has a significant cardioprotective effect on breast cancer patients receiving anthracycline chemotherapy. However, the pharmacoeconomics of anthracycline combined with dexamethimide in the treatment of breast cancer is extremely limited, and more research is needed to verify it.
【作者單位】： 中國藥科大學(xué)國際醫(yī)藥商學(xué)院;北京大學(xué)中國衛(wèi)生經(jīng)濟(jì)研究中心;
【分類號(hào)】：R737.9

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