發(fā)布時間：2018-04-14 14:05

  本文選題：甲狀腺乳頭狀癌 + 血小板/淋巴細(xì)胞比值��； 參考：《北京協(xié)和醫(yī)學(xué)院》2015年碩士論文

【摘要】：目的：探究術(shù)前血小板／淋巴細(xì)胞比值(PLR)、中性粒細(xì)胞／淋巴細(xì)胞比值(NLR)對甲狀腺乳頭狀癌無復(fù)發(fā)生存的預(yù)測價值。方法：回顧性分析1999年1月至1999年12月間在我院頭頸外科經(jīng)手術(shù)初治的135例甲狀腺乳頭狀癌患者的臨床資料,根據(jù)患者術(shù)前外周靜脈血PLR、NLR值,采用ROC曲線,將病例資料分為低PLR組(PLR≤150)和高PLR組(PLR150)、低NLR組(NLR3)和高NLR組(NLR≥3),比較各組患者的15年無復(fù)發(fā)生存率,并采用Cox模型多因素分析,探究PLR、NLR是否為影響甲狀腺乳頭狀癌術(shù)后無復(fù)發(fā)生存的獨立危險因素。結(jié)果：1.低PLR組101例術(shù)后無復(fù)發(fā)生存率為83.4%,高PLR組34例術(shù)后無復(fù)發(fā)生存率為45.4%,低PLR組術(shù)后無復(fù)發(fā)生存率高于高PLR組術(shù)后無復(fù)發(fā)生存率,組間差異有統(tǒng)計學(xué)意義(X2=18.260,P0.001)2.低NLR組58例術(shù)后無復(fù)發(fā)生存率為85.7%,高NLR組77例術(shù)后無復(fù)發(fā)生存率為64.1%,低NLR組術(shù)后無復(fù)發(fā)生存率高于高NLR組術(shù)后無復(fù)發(fā)生存率,組間差異有統(tǒng)計學(xué)意義(X2=7.146,P=0.008)3.將單因素分析中有統(tǒng)計學(xué)意義(P0.05)的變量納入Cox模型多因素分析可得,術(shù)前PLR、NLR是影響本組甲狀腺乳頭狀癌術(shù)后復(fù)發(fā)的獨立危險因素。結(jié)論：術(shù)前PLR、NLR對甲狀腺乳頭狀癌患者術(shù)后無復(fù)發(fā)生存具有預(yù)測價值,兩者均是便捷、經(jīng)濟(jì)的檢測指標(biāo),在患者術(shù)前血常規(guī)分析中即可獲得；既不增加患者負(fù)擔(dān),也可方便獲取。PLR150或NLR≥3提示PTC患者預(yù)后較差,可以考慮作為PTC預(yù)后的判斷指標(biāo),以期指導(dǎo)臨床治療。
[Abstract]:Objective: to investigate the prognostic value of preoperative platelet / lymphocyte ratio (PLR) and neutrophil / lymphocyte ratio (NLR) in the survival of papillary thyroid carcinoma without recurrence.Methods: the clinical data of 135 patients with papillary thyroid carcinoma treated in head and neck surgery between January 1999 and December 1999 were retrospectively analyzed. The ROC curve was used according to the peripheral venous blood of the patients before operation.The patients were divided into three groups: low PLR group (P < 150), high PLR group (n = 150), low NLR group (n = 3) and high NLR group (n = 3). The 15-year recurrence free survival rate of the patients in each group was compared, and the multivariate analysis of Cox model was used.To investigate whether PLRN-NLR is an independent risk factor for recurrence-free survival of papillary thyroid carcinoma.The result is 1: 1.The recurrence free survival rate in low PLR group was 83.4%, and that in high PLR group was 45.45.The recurrence free survival rate in low PLR group was higher than that in high PLR group. The difference between the two groups was statistically significant.The recurrence free survival rate was 85.7 in the low NLR group and 64.1 in the high NLR group. The recurrence free survival rate in the low NLR group was higher than that in the high NLR group. The difference between the two groups was statistically significant.The variables with statistical significance in univariate analysis (P0.05) were included in the multivariate analysis of Cox model. Preoperative Cox NLR was an independent risk factor for postoperative recurrence of papillary thyroid carcinoma.Conclusion: preoperative PLRV NLR has predictive value for postoperative recurrence free survival in patients with papillary thyroid carcinoma. Both of them are convenient and economical indexes, which can be obtained in preoperative blood routine analysis, and do not increase the burden of thyroid papillary carcinoma.It is also convenient to obtain. PLR150 or NLR 鈮，

本文編號：1749619