本文選題：原發(fā)性肝癌 + 門靜脈癌栓�。� 參考：《蚌埠醫(yī)學(xué)院》2015年碩士論文

【摘要】：目的總結(jié)原發(fā)性肝癌合并門靜脈癌栓的發(fā)生率,并探討肝癌患者形成門靜脈癌栓的相關(guān)因素,提高對PTVV的全面認(rèn)識,為臨床HCC伴PVTT的防治提供依據(jù)及達(dá)到更好療效。方法回顧性分析我科2013年9月至2014年9月67例原發(fā)性肝癌患者的生化檢查、臨床表現(xiàn)、影像學(xué)資料和病歷資料等,總結(jié)門靜脈癌栓在肝癌患者中的發(fā)生率。根據(jù)影像學(xué)檢查及手術(shù)探查結(jié)果,分為門靜脈癌栓組22例,無門靜脈癌栓組45例,單因素分析和多因素Logistic回歸分析方法分析兩組的年齡、性別、腫瘤的中心位置、有無肝硬化基礎(chǔ)、有無乙肝、Child分級、腹水、門靜脈高壓、上消化道出血、ALT、AST、ALP、GGT、TBIL、ALB、AFP、PT、PLT等臨床資料與PVTT形成的相關(guān)性,得出PVTT形成的相關(guān)危險因素。結(jié)果HCC患者伴PVTT形成者占32.8%,單因素分析提示門靜脈癌栓形成與ALT、ALP、GGT、AFP、Child分級、腹水、門靜脈高壓、消化道出血有關(guān),多因素Logistic回歸分析提示ALP、GGT、AFP、腹水是肝癌伴門脈癌栓形成的危險因素。結(jié)論原發(fā)性肝癌患者伴門靜脈癌栓形成的發(fā)生率高。血清ALP、GGT、AFP升高并形成腹水的患者容易誘發(fā)形成門靜脈癌栓,為原發(fā)性肝癌患者形成門脈癌栓的獨(dú)立危險因素。
[Abstract]:Objective to summarize the incidence of primary liver cancer complicated with portal vein tumor thrombus, and to explore the related factors of portal vein tumor thrombus formation in patients with primary liver cancer, to improve the overall understanding of PTVV, and to provide evidence for the prevention and treatment of HCC with PVTT and to achieve better curative effect.Methods from September 2013 to September 2014, 67 patients with primary liver cancer were retrospectively analyzed for their biochemical examination, clinical manifestations, imaging data and medical records, and the incidence of portal vein tumor thrombus in patients with liver cancer was summarized.According to the results of imaging examination and surgical exploration, the patients were divided into two groups: the portal vein tumor thrombus group (n = 22) and the non-portal vein tumor thrombus group (n = 45). The age, sex and central location of the tumor were analyzed by univariate analysis and multivariate Logistic regression analysis.The correlation between the clinical data and the formation of PVTT was found, such as the basis of cirrhosis, the classification of hepatitis B, ascites, portal hypertension, upper gastrointestinal hemorrhage, ALTAST, TBILT, ALB, AFP, PTPLT, and so on. The risk factors related to the formation of PVTT were obtained.Results the incidence of PVTT in patients with HCC was 32.8%. Univariate analysis showed that the formation of portal vein tumor thrombus was related to the grade of AFP Child, ascites, portal hypertension and gastrointestinal bleeding. The multivariate Logistic regression analysis suggested that the ascites were the risk factors for the formation of hepatic carcinoma with portal vein tumor thrombus.Conclusion the incidence of portal vein thrombosis in patients with primary liver cancer is high.Patients with elevated serum ALP GGT AFP and ascites were prone to develop portal vein tumor thrombus, which was an independent risk factor for portal vein tumor thrombus in patients with primary liver cancer.
【學(xué)位授予單位】：蚌埠醫(yī)學(xué)院
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R735.7

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本文編號：1749272