本文選題：咖啡酸片 + 腫瘤化療��； 參考：《中國腫瘤臨床》2017年17期

【摘要】：目的:觀察咖啡酸片治療腫瘤化療所致血小板減少癥(chemotherapy induced thrombocytopenia,CIT)的臨床療效及安全性。方法:采用自身對照的方法,選取上海交通大學醫(yī)學院附屬瑞金醫(yī)院等11家三級甲等醫(yī)院2016年1月22日至2017年1月10日收治的60例腫瘤化療所致CIT患者。給予咖啡酸片/模擬劑治療,均為3片/次,3次/d。第1個化療周期(陰性對照期)于化療開始第1 d給予咖啡酸片模擬劑;第2、3個化療周期(藥物治療期)需要接受與第1個化療周期相同方案及劑量的化療,分別于化療開始第1 d給予咖啡酸片。結(jié)果:藥物治療期最低血小板(platelet,PLT)的升高值顯著高于陰性對照期(P0.001);藥物治療期化療后,PLT恢復后最高值顯著高于陰性對照期(P0.001);藥物治療期PLT50×10~9/L的持續(xù)天數(shù)與陰性對照期無顯著性差異,但有縮短趨勢(P0.05);藥物治療期化療后PLT恢復至≥75×10~9/L和≥100×10~9/L,所需的天數(shù)較陰性對照期均明顯減少(P0.001);試驗期間無患者行PLT輸注。結(jié)論:咖啡酸片用于腫瘤化療所致CIT患者,療效確切,不良反應較少,具有廣泛的臨床應用前景。
[Abstract]:Objective: to observe the clinical efficacy and safety of caffeic acid tablets in the treatment of induced thrombocytopenia caused by tumor chemotherapy-induced thrombocytopenia.Methods: by using self-control method, 60 patients with CIT caused by tumor chemotherapy were selected from 11 Grade 3A hospitals such as Ruijin Hospital, Shanghai Jiaotong University Medical College from January 22, 2016 to January 10, 2017.Caffeic acid tablets / analogue were treated with 3 tablets / 3 times / d.The first chemotherapy cycle (negative control period) was treated with caffeic acid tablet mimics on the first day of chemotherapy, and the 2nd and 3rd chemotherapy cycles (drug treatment period) required the same regimen and dose of chemotherapy as the first chemotherapy cycle.Caffeic acid tablets were given on the first day of chemotherapy.Results: the elevated value of PLT was significantly higher than that of the negative control group (P 0.001), the highest value after chemotherapy was significantly higher than that in the negative control group (P 0.001), and the duration of PLT50 脳 10 9 / L in the drug treatment phase was not significantly different from that in the negative control group.However, there was a tendency to shorten P0. 05%, PLT recovered to 鈮，

本文編號：1744932