本文選題：外泌體 + 腫瘤微環(huán)境　； 參考：《河北醫(yī)科大學(xué)》2017年碩士論文

【摘要】：外泌體(exosomes)是由雙層脂質(zhì)膜形成的圓形囊泡,其直徑在30到100nm之間,呈圓盤狀結(jié)構(gòu)。外泌體形成于多泡體,大多數(shù)的組織細(xì)胞將外泌體分泌于各種體液環(huán)境或者細(xì)胞培養(yǎng)基之中。在外泌體形成的過程中包裹了來自母體細(xì)胞的mi RNA、m RNA、DNA序列及蛋白質(zhì)等成分,其具有母體細(xì)胞的一些功能和特點(diǎn)。外泌體是細(xì)胞之間交流的“橋梁”,影響靶細(xì)胞的功能。研究發(fā)現(xiàn),外泌體在生理或病理狀態(tài)(特別是發(fā)生腫瘤時(shí))具有不可替代的作用。這篇文章著重介紹了外泌體在腫瘤發(fā)生、發(fā)展、腫瘤微環(huán)境的形成、腫瘤免疫、液體活檢及藥物傳遞方面的研究進(jìn)展,并提出了一些亟待解決的問題。
[Abstract]:Exocrine vesicles are circular vesicles formed by bilayer lipid membranes, whose diameters range from 30 to 100nm, with a disc structure.Exocrine was formed in vesicles, and most of the tissues secreted the exocrine in various humoral environment or cell culture medium.During the process of exocrine formation, the DNA sequences and proteins of the miRNA-mRNAs from the mother cells were encapsulated, which had some functions and characteristics of the mother cells.Exocrine is a bridge between cells, affecting the function of target cells.It has been found that exocrine plays an irreplaceable role in physiological or pathological state, especially in tumorigenesis.This article focuses on the development of exocrine in tumorigenesis, development, the formation of tumor microenvironment, tumor immunity, fluid biopsy and drug delivery, and puts forward some problems to be solved.
【學(xué)位授予單位】：河北醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R730.2

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 李思迪;侯信;亓洪昭;趙瑾;原續(xù)波;;外泌體:為高效藥物投遞策略提供天然的內(nèi)源性納米載體[J];化學(xué)進(jìn)展;2016年Z2期

，

本文編號(hào)：1742228