本文選題：PI-RADS + v�。� 參考：《南方醫(yī)科大學(xué)學(xué)報》2017年08期

【摘要】：目的建立前列腺影像報告和數(shù)據(jù)系統(tǒng)第2版(PI-RADS v2)與前列腺特異性抗原(PSA)結(jié)合的Logistic回歸預(yù)測模型,評價其對外周帶前列腺癌的診斷能力。方法回顧性分析經(jīng)病理證實的外周帶前列腺69例、非前列腺癌109例的患者術(shù)前MRI及前列腺特異性抗原資料。應(yīng)用PI-RADS v2對外周帶前列腺癌行發(fā)病風(fēng)險評分。分析外周帶前列腺癌組與非前列腺癌組PI-RADS v2評分、總PSA、游離與總PSA比值、前列腺特異性抗原密度(PSAD)及外周帶前列腺特異性抗原密度(PZ-PSAD)指標(biāo)的差異,選擇具有統(tǒng)計學(xué)意義的指標(biāo)作為自變量,以病理結(jié)果是否為前列腺癌作為因變量,擬建立四項Logistic回歸模型:A、PI-RADS v2+總PSA;B、PI-RADS v2+游離與總PSA比值;C、PI-RADS v2+PSAD;D、PI-RADS v2+PZ-PSAD,建立Logistic回歸模型產(chǎn)生的P和PI-RADS v2評分的受試者工作曲線,評估其診斷效能。結(jié)果前列腺癌組與非前列腺癌組PI-RADS v2評分、總PSA、游離與總PSA比值、PSAD、PZ-PSAD差異有統(tǒng)計學(xué)意義(P0.01),納入因變量。外周帶前列腺癌Logistic回歸預(yù)測模型建立如下:A:Logit P=-6.825+1.024PI-RADS v2+0.223總PSA、B:Logit P=-4.354+1.586PI-RADS v2-12.7841游離與總PSA比值、C:Logit P=-8.993+1.630PI-RADS v2+17.091PSAD、D:Logit P=-9.434+1.596PI-RADS v2+10.494PZ-PSAD。A、B、C、D模型產(chǎn)生的Logit P預(yù)測概率,其受試者工作曲線下面積高于PI-RADS v2,差異具有統(tǒng)計學(xué)意義(Z=2.44、2.68、3.11、3.41,P0.05)。結(jié)論聯(lián)合PI-RADS v2評分與前列腺特異性抗原指標(biāo)的Logistic回歸預(yù)測模型對外周帶前列腺癌的診斷效能優(yōu)于單獨使用PI-RADS v2評分,為可疑外周帶前列腺癌患者行穿刺提供了更可靠的依據(jù)。
[Abstract]:Objective to establish a Logistic regression predictive model combined with prostate specific antigen (PSA) in the second edition of the prostate imaging report and data system (PI-RADS v2), and to evaluate its diagnostic ability in peripheral prostate cancer.Methods the data of preoperative MRI and prostate specific antigen in 69 cases of peripheral prostate and 109 cases of non-prostatic carcinoma were analyzed retrospectively.PI-RADS v2 was used to evaluate the risk of peripheral prostate cancer.The difference of PI-RADS v2 score, total PSAs, ratio of free to total PSA, prostate specific antigen density (PSA) and peripheral zone prostate specific antigen density (PZ-PSAD) between peripheral prostate cancer group and non-prostate cancer group were analyzed.Select statistically significant indicators as independent variables, and whether the pathological results are prostate cancer as dependent variables,Four Logistic regression models, the ratio of free to total PSA of PSA-RADS v2, PI-RADS v2 PSAD2, PI-RADS v2 PZ-PSAD, were established. The operating curves of subjects with P and PI-RADS v2 scores produced by Logistic regression model were established and their diagnostic efficacy was evaluated.Results there were significant differences in PI-RADS v2 score, total PSA and free to total PSA ratio between prostate cancer group and non-prostate cancer group (P 0.01).The area under the operating curve of the subjects was higher than that of PI-RADS v2, and the difference was statistically significant.
【作者單位】： 南方醫(yī)科大學(xué)南方醫(yī)院影像中心;
【基金】：廣東省科技計劃項目(2015B010131011)
【分類號】：R445.2;R737.25

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