本文選題：外泌體 + 腫瘤　； 參考：《中華腫瘤防治雜志》2017年09期

【摘要】：目的腫瘤細(xì)胞分泌的外泌體(tumor-derived exosomes,TDEs)中包含蛋白質(zhì)、脂質(zhì)和核酸等多種組分,能夠參與細(xì)胞間的信息交流,從而調(diào)節(jié)腫瘤發(fā)生、血管生成、侵襲和轉(zhuǎn)移等,為癌癥的診斷提供了豐富的腫瘤生物標(biāo)志物分子源。同時,也有越來越多的研究將TDEs及其加工修飾產(chǎn)物作為一種新的癌癥疫苗和藥物遞送載體用于癌癥的治療。本研究總結(jié)國內(nèi)外對TDEs在腫瘤診斷和治療研究中的應(yīng)用現(xiàn)狀。方法檢索PubMed及CNKI期刊全文數(shù)據(jù)庫檢索系統(tǒng),以"外泌體、腫瘤、生物標(biāo)記物和治療"為關(guān)鍵詞,檢索2006-01-2016-10關(guān)于外泌體研究的文獻(xiàn),共檢索英文文獻(xiàn)569篇,中文文獻(xiàn)79篇。納入標(biāo)準(zhǔn):(1)TDEs的生物學(xué)功能;(2)TDEs作為作為腫瘤生物標(biāo)記物的應(yīng)用研究;(3)TDEs作為腫瘤治療靶點的研究。根據(jù)納入標(biāo)準(zhǔn),符合分析的文獻(xiàn)54篇。結(jié)果 TDEs作為細(xì)胞之間信息交流的載體,具有調(diào)節(jié)腫瘤發(fā)生、侵襲和轉(zhuǎn)移等的生物學(xué)功能。TDEs中包含豐富的腫瘤標(biāo)志分子,TDEs及其加工修飾產(chǎn)物可作為一種新的癌癥疫苗和藥物遞送載體用于疾病的治療。結(jié)論 TDEs可以成為腫瘤診治的理想靶點,但在臨床應(yīng)用方面仍有很多問題需要解決。
[Abstract]:Objective tumor-derived exosomes (TDEs) secreted by tumor cells contain proteins, lipids and nucleic acids, which can participate in the communication of information between cells, thereby regulating tumorigenesis, angiogenesis, invasion and metastasis.It provides abundant molecular sources of tumor biomarkers for the diagnosis of cancer.At the same time, more and more studies have used TDEs and its modified products as a new cancer vaccine and drug delivery vector for cancer treatment.This study summarizes the application of TDEs in tumor diagnosis and treatment.Methods the PubMed and CNKI periodical full-text database retrieval system was searched. With the key words of exocrine body, tumor, biomarkers and therapy, the literature on exocrine body was searched from January to October 2016-2006. A total of 569 articles in English and 79 articles in Chinese were searched.Application of TDEs as tumor biomarker the study of TDEs as the target of tumor therapy.According to the inclusion criteria, 54 articles were analyzed.Results as a carrier of information exchange between cells, TDEs can regulate tumorigenesis.Biological functions of invasion and Metastasis. TDEs contain abundant tumor markers, TDEs and their modified products can be used as a new cancer vaccine and drug delivery vector for the treatment of diseases.Conclusion TDEs can be an ideal target for tumor diagnosis and treatment, but there are still many problems to be solved in clinical application.
【作者單位】： 濟(jì)南大學(xué)·山東省醫(yī)學(xué)科學(xué)院醫(yī)學(xué)與生命科學(xué)學(xué)院;山東大學(xué)附屬山東省腫瘤醫(yī)院基礎(chǔ)實驗室;
【分類號】：R730.2

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