本文選題：食管鱗癌　切入點：AGGF1　出處：《新疆醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:食管鱗狀細胞癌是一種比較常見的上消化道惡性腫瘤,放射治療是食管鱗癌的主要治療方法之一。本研究旨在探討食管鱗癌組織中AGGF1和HIF-1α及VEGF的表達情況,及其與食管鱗癌的臨床病理特征、放療療效及預(yù)后的關(guān)系。方法:該研究采用免疫組化SP法,檢測新疆醫(yī)科大學(xué)附屬腫瘤醫(yī)院胸腹放療科2011-01-01—2015-01-01收治的79例食管鱗癌和20例正常食管組織中AGGF1、HIF-1α和VEGF的表達,結(jié)合臨床病理特征和隨訪資料進行相關(guān)研究分析。結(jié)果:79例食管鱗癌中AGGF1(χ2=18.975,P0.001)、HIF-1α(χ2=26.884,P0.001)和VEGF(χ2=22.702,P0.001)的表達顯著高于20例正常食管組織中的表達。食管鱗癌中AGGF1(χ2=8.134,P=0.004)和VEGF(χ2=5.175,P=0.023)的表達與淋巴結(jié)轉(zhuǎn)移密切相關(guān);HIF-1α的表達與臨床分期(χ2=5.882,P=0.015)、淋巴結(jié)轉(zhuǎn)移(χ2=7.712,P=0.005)和浸潤深度(χ2=5.538,P=0.019)密切相關(guān)。食管鱗癌中VEGF和HIF-1α的表達呈正相關(guān)(r=0.333,P=0.003);AGGF1和VEGF的表達呈正相關(guān)(r=0.790,P0.001)。放療近期療效與HIF-1α的表達呈負相關(guān)(r=-0.246,P=0.029)。AGGF1(P=0.170)和VEGF(P=0.229)陽性表達組OS短于陰性組;HIF-1α陽性表達組OS顯著短于陰性組(P=0.013)。Cox多因素回歸分析顯示,HIF-1α陽性表達(P=0.002)、浸潤深度(P=0.005)和臨床分期(P0.001)是食管鱗癌患者生存預(yù)后的影響因素。結(jié)論:AGGF1,HIF-1α及VEGF在食管鱗癌組織中高表達,并與食管鱗癌臨床病理特征密切相關(guān),三者高表達可能對食管鱗癌的放療療效和生存預(yù)后有影響,可為提高食管鱗癌的放療效果和改善生存預(yù)后提供新的思路和方法。
[Abstract]:Objective: esophageal squamous cell carcinoma is a common malignant tumor of upper digestive tract, radiotherapy is one of the main treatment methods of esophageal squamous cell carcinoma.The purpose of this study was to investigate the expression of AGGF1, HIF-1 偽 and VEGF in esophageal squamous cell carcinoma and its relationship with the clinicopathological features, radiotherapy efficacy and prognosis of esophageal squamous cell carcinoma.Methods: immunohistochemical SP method was used to detect the expression of AGGF1HIF-1 偽 and VEGF in 79 cases of esophageal squamous cell carcinoma and 20 cases of normal esophageal tissues treated in Department of chest and abdominal radiotherapy, affiliated Cancer Hospital of Xinjiang Medical University, 2011-01-01-2015-01-01.Combined with clinicopathological features and follow-up data to carry out related research and analysis.Results the expression of AGGF-1 偽 and VEGF in 79 cases of esophageal squamous cell carcinoma were significantly higher than those in 20 normal esophageal tissues.There was a positive correlation between the expression of VEGF and HIF-1 偽 in esophageal squamous cell carcinoma.It is a prognostic factor of esophageal squamous cell carcinoma.Conclusion the high expression of HIF-1 偽 and VEGF in esophageal squamous cell carcinoma is closely related to the clinicopathological features of esophageal squamous cell carcinoma. The overexpression of these three proteins may have an effect on the radiotherapy efficacy and survival prognosis of esophageal squamous cell carcinoma.It can provide new ideas and methods for improving radiotherapy effect and survival prognosis of esophageal squamous cell carcinoma.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R735.1

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