本文選題：前列腺癌　切入點(diǎn)：雄激素剝奪治療　出處：《山西醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的探討晚期前列腺癌(PCa)間歇性雄激素剝奪治療(IADT)和持續(xù)性雄激素剝奪治療(CADT)兩種不同方式與繼發(fā)糖尿病(DM)和糖耐量異常(IGT)風(fēng)險(xiǎn)的相關(guān)性。方法:對2013年1月至2015年12月于我院進(jìn)行ADT的PCa患者進(jìn)行回顧性病例對照研究。通過監(jiān)測患者空腹血糖、餐后2小時血糖及口服糖耐量試驗(yàn),結(jié)合患者相關(guān)臨床癥狀,對IADT和CADT引起DM和IGT的風(fēng)險(xiǎn)進(jìn)行統(tǒng)計(jì)學(xué)分析,并分析組內(nèi)體質(zhì)指數(shù)(BMI)、高血壓、吸煙、飲酒等因素與繼發(fā)性DM和IGT的關(guān)系。結(jié)果:IADT組53例(46.5%),平均(69.1±4.3)歲;CADT組61例(53.5%),平均(70.2±5.7)歲,兩組在臨床特點(diǎn)方面均無明顯差異(p均0.05);IADT組體質(zhì)指數(shù)、高血壓、吸煙、飲酒等因素對DM、IGT的發(fā)生均無明顯影響(p均0.05),CADT組BMI、高血壓、吸煙、飲酒等因素對DM、IGT的發(fā)生均無明顯影響(p均0.05);IADT組與CADT組比較,對引起DM發(fā)生無統(tǒng)計(jì)學(xué)差異(P=0.643);但對引起IGT發(fā)生差異有統(tǒng)計(jì)學(xué)意義(P=0.029)。結(jié)論:IADT與CADT相比,雖然在引起繼發(fā)DM上沒有差異,但是IADT降低了糖代謝紊亂的發(fā)生,把DM遏制在前期狀態(tài),在一定程度上降低了繼發(fā)DM的發(fā)生,IADT安全性相對CADT高。
[Abstract]:Objective to investigate the effect of advanced prostate cancer (PCa) intermittent androgen deprivation therapy (IADT) and continuous androgen deprivation therapy (CADT) in two different ways and secondary diabetes mellitus (DM) and impaired glucose tolerance (IGT) risk correlation. Methods from January 2013 to December 2015 in our hospital ADT PCa underwent retrospective control study cases. The patients with fasting blood glucose monitoring, 2 hour postprandial blood glucose and oral glucose tolerance test combined with clinical symptoms in patients with IADT and CADT, DM and IGT of the risk caused by statistical analysis and group analysis of body mass index (BMI), hypertension, smoking, drinking and other factors and the relationship between DM and secondary IGT. Results: IADT group of 53 cases (46.5%), average (69.1 + 4.3); CADT group of 61 cases (53.5%), average (70.2 + 5.7) years old, the two groups in clinical characteristics did not differ significantly (P < 0.05); group IADT, BMI, hypertension, smoking, drinking, etc. factor For DM, had no effect on the occurrence of IGT (P 0.05), CADT group, BMI, hypertension, smoking, drinking and other factors on the DM, had no effect on the occurrence of IGT (P 0.05); IADT group compared with CADT group, the incidence of DM caused no significant difference (P=0.643); but for the cause IGT. The difference was statistically significant (P=0.029). Conclusion: IADT compared with CADT, although there is no difference in the cause of secondary DM, but IADT reduced sugar metabolic disorders, the DM containment in the early state, to a certain extent, reduce the secondary DM, IADT CADT security is relatively high.

【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R737.25;R587.1

【參考文獻(xiàn)】

相關(guān)期刊論文 前3條

1 孫忠全;沈志遠(yuǎn);;睪酮與前列腺癌研究進(jìn)展[J];中華男科學(xué)雜志;2014年08期

2 韓蘇軍;張思維;陳萬青;李長嶺;;中國前列腺癌發(fā)病現(xiàn)狀和流行趨勢分析[J];臨床腫瘤學(xué)雜志;2013年04期

3 馮憑;葡萄糖耐量低減[J];國外醫(yī)學(xué)(內(nèi)分泌學(xué)分冊);2002年06期

，

本文編號：1706136