發(fā)布時間：2018-04-01 00:21

  本文選題：原始神經外胚層腫瘤　切入點：發(fā)病特征　出處：《實用醫(yī)學雜志》2017年15期

【摘要】：目的探討原始神經外胚層腫瘤(PNET)的臨床特征及預后。方法收集2011年3月至2015年3月確診的PNET患者臨床資料,共52例,總結其臨床特點及治療情況。計算總體1、2、3年生存率,中位無疾病進展期(PFS)和中位生存期(OS);單因素生存分析用K-M法,多因素分析用COX回歸;分析不同預后因素對OS的影響。結果 CD99、FLI-1是診斷PNET重要免疫組化指標,陽性率分別為95.9%,95.0%。EWSR1基因檢測可提高PNET診斷的特異性和敏感度,陽性率85.7%�？傮w中位PFS 10月,中位OS 18月,1、2、3年生存率分別為76.9%、42.6%、17.7%。單因素分析:OS與腫瘤位置、分期、治療方案相關,而與發(fā)病年齡、性別無關。COX多因素分析:腫瘤位置、分期和治療方案是影響預后的獨立因素。結論Ⅰ~Ⅱ期,腫瘤位于非中線部位,采用手術、放療、化療綜合治療的患者預后好。
[Abstract]:Objective to investigate the clinical features and prognosis of primitive neuroectodermal tumor (PNET). Methods 52 patients with PNET diagnosed from March 2011 to March 2015 were collected and their clinical characteristics and treatment were summarized. COX regression was used for univariate survival analysis and COX regression for multivariate analysis, and the influence of different prognostic factors on OS was analyzed. Results CD99 FLI-1 was an important immunohistochemical index in the diagnosis of PNET. The positive rate of EWSR1 gene was 95.9% and 95.0%, respectively. The positive rate was 85.7%. The overall median PFS in October, the median OS in 18 months and the 3-year survival rate were 76.9% and 42.6%, respectively. Univariate analysis showed that the positive rate was related to tumor location, stage, and treatment plan. Cox multivariate analysis showed that tumor location, stage and treatment regimen were independent factors affecting prognosis. Conclusion in stage 鈪，

本文編號：1693141