本文選題：磁小體　切入點(diǎn)：趨磁細(xì)菌　出處：《中國(guó)科學(xué):生命科學(xué)》2017年05期

【摘要】：趨磁細(xì)菌產(chǎn)生的磁小體是生物膜包被的磁性納米顆粒,具有優(yōu)良的納米磁特性;相比化學(xué)合成的磁性納米材料,其生物來(lái)源賦予磁小體更好的生物相容性和遺傳可操作性.在生物醫(yī)學(xué)領(lǐng)域,除了用于磁熱療進(jìn)行腫瘤治療外,最近幾年其作為靶向藥物載體、可能參與腫瘤微環(huán)境調(diào)控的性質(zhì)得到研究者的廣泛關(guān)注;同時(shí)DNA重組技術(shù)的發(fā)展解決了磁小體的產(chǎn)率低而趨磁細(xì)菌難培養(yǎng)的問題.本文綜述了磁小體的生物合成及其相關(guān)研究進(jìn)展,并對(duì)其應(yīng)用前景進(jìn)行了展望.
[Abstract]:Magnetic bodies produced by magnetotactic bacteria are biofilm-coated magnetic nanoparticles with excellent nanomagnetic properties, compared with chemically synthesized magnetic nanomaterials, Its biological sources give magnetic bodies better biocompatibility and genetic maneuverability. In the biomedical field, in addition to magnetothermal therapy for cancer treatment, in recent years it has been used as a targeted drug carrier. The nature of possible involvement in the regulation of tumor microenvironment has been widely concerned by researchers. At the same time, the development of DNA recombination technology has solved the problem of low yield of magnetic bodies and difficult to culture magnetotactic bacteria. In this paper, the biosynthesis of magnetic bodies and their related research progress are reviewed, and the prospect of their application is prospected.
【作者單位】： 山東大學(xué)生命科學(xué)學(xué)院山東大學(xué)-亥姆霍茲生物技術(shù)研究所微生物技術(shù)國(guó)家重點(diǎn)實(shí)驗(yàn)室;
【基金】：國(guó)家自然科學(xué)基金(批準(zhǔn)號(hào):31670097) 科技部國(guó)際合作專項(xiàng)(批準(zhǔn)號(hào):2015DFE32850) 山東省重點(diǎn)研發(fā)計(jì)劃(批準(zhǔn)號(hào):2015GSF12101) 山東省重大專項(xiàng)(批準(zhǔn)號(hào):2015ZDJS04001)
【分類號(hào)】：R730.5

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相關(guān)碩士學(xué)位論文 前2條

1 謝茂彬;趨磁細(xì)菌AMB-1磁小體構(gòu)建磁靶向抗癌藥物投遞系統(tǒng)[D];華僑大學(xué);2012年

2 劉杰;腫瘤磁感應(yīng)熱療新型磁性納米介質(zhì)的研究[D];北京中醫(yī)藥大學(xué);2011年

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本文編號(hào)：1689056