本文選題：三陰性乳腺癌　切入點(diǎn)：新輔助化療　出處：《中國(guó)地方病防治雜志》2017年08期 　論文類(lèi)型：期刊論文

【摘要】：目的探討新輔助化療方案對(duì)三陰性乳腺癌的療效及其對(duì)患者血清血清瘦素(LEP)、胰島素樣生長(zhǎng)因子-1(IGF-1)以及腫瘤壞死因子α(TNF-α)水平的影響。方法將入住本院的90例TNBC患者按照隨機(jī)數(shù)字表法分為對(duì)照組與觀察組,各45例。對(duì)照組采用常規(guī)化療方案:80 mg/m~2的奈達(dá)鉑(d1)+1 000 mg/m~2的吉西他濱(d1,d8),靜滴;觀察組采用新輔助化療方案:75 mg/m~2的多西他賽(d1)+1 000 mg/m~2卡培他濱(d1~14),每3周為一個(gè)化療周期,化療周期均為2個(gè)周期。比較兩組臨床控制總有效率及臨床收益率、治療前后血清LEP、IGF-1及TNF-α水平、毒副反應(yīng)發(fā)生情況。結(jié)果觀察組臨床控制總有效率及臨床收益率均高于對(duì)照組;觀察組患者治療后血清LEP水平均低于治療前及對(duì)照組治療后,觀察組患者治療后IGF-1及TNF-α水平均高于治療前及對(duì)照組治療后,以上差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組患者毒副反應(yīng)(貧血、中性粒細(xì)胞減少、血小板減少、惡心嘔吐、便秘以及脫發(fā))發(fā)生率差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論新輔助化療方案可通過(guò)改善TNBC患者血清LEP、IGF-1、TNF-α的水平而發(fā)揮作用,應(yīng)在臨床中進(jìn)行推廣。
[Abstract]:Objective to investigate the effect of neoadjuvant chemotherapy regimen on tri-negative breast cancer and its effect on serum leptin, insulin-like growth factor-1 IGF-1 (IGF-1) and tumor necrosis factor 偽 (TNF- 偽) levels. Methods 90 patients with TNBC were enrolled in our hospital. According to the random digital table method, they were divided into control group and observation group. There were 45 cases in each group. The control group was treated with routine chemotherapy regimen of: 80 mg/m~2 / d1) (1 000 mg/m~2) of gemcitabine d1 + d8 (iv); the control group was treated with neo-adjuvant chemotherapy regimen (1: 75 mg/m~2) of docetaxel d1) 1 000 mg/m~2 capecitabine d1 (14), every 3 weeks as a chemotherapy cycle, and the control group was treated with a new adjuvant chemotherapy regimen (1: 75 mg/m~2). The total effective rate of clinical control and clinical rate of return were compared between the two groups, the levels of serum LEPnIGF-1 and TNF- 偽 before and after treatment, and the occurrence of side effects. Results the total effective rate of clinical control and the clinical rate of return in the observation group were higher than those in the control group. The levels of serum LEP in observation group were lower than those before treatment and after treatment in control group. The levels of IGF-1 and TNF- 偽 in observation group were higher than those before treatment and after treatment in control group. There were significant differences between the two groups (anemia, neutropenia, thrombocytopenia, nausea and vomiting). There was no significant difference in the incidence of constipation and alopecia (P 0.05). Conclusion Neoadjuvant chemotherapy regimen can improve the serum level of LEP- IGF-1 and TNF- 偽 in patients with TNBC, and should be popularized in clinical practice.
【作者單位】： 復(fù)旦大學(xué)附屬腫瘤醫(yī)院閔行分院;
【基金】：閔行區(qū)衛(wèi)生和計(jì)劃生育委員會(huì)科研項(xiàng)目
【分類(lèi)號(hào)】：R737.9

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