本文選題：T細(xì)胞免疫球蛋白和黏蛋白域分子　切入點(diǎn)：非小細(xì)胞肺癌　出處：《中國癌癥雜志》2017年07期 　論文類型：期刊論文

【摘要】：背景與目的:T細(xì)胞免疫球蛋白和黏蛋白域分子3(T cell immunoglobulin and mucin-domaincontaining molecules 3,Tim-3)在免疫調(diào)節(jié)中起重要作用,參與多種疾病的發(fā)生、發(fā)展,且與疾病免疫逃逸和疾病臨床預(yù)后明顯相關(guān)。該研究旨在探討負(fù)性共刺激分子Tim-3在非小細(xì)胞肺癌(non-small cell lung cancer,NSCLC)浸潤巨噬細(xì)胞中的表達(dá)及臨床意義。方法:采用免疫組織化學(xué)法檢測(cè)126例NSCLC患者中Tim-3的表達(dá)水平,分析腫瘤組織浸潤巨噬細(xì)胞Tim-3的表達(dá)水平與臨床病理特征間的關(guān)系,并進(jìn)一步分析Tim-3的表達(dá)水平對(duì)NSCLC患者預(yù)后的影響。結(jié)果:Tim-3主要分布于巨噬細(xì)胞的細(xì)胞質(zhì)和細(xì)胞膜中;Tim-3在腫瘤浸潤巨噬細(xì)胞中的表達(dá)水平與腫瘤大小、淋巴結(jié)轉(zhuǎn)移及TNM分期均顯著相關(guān)(P=0.002、0.045和0.022);Tim-3在腫瘤浸潤巨噬細(xì)胞中的表達(dá)水平可顯著影響NSCLC患者的生存及預(yù)后,在Ⅲ期NSCLC患者中,Tim-3的表達(dá)越高,患者總生存期(overall survival,OS)越短(Ⅲ期:χ~2=12.910,P=0.000,中位OS分別為80和32個(gè)月)。而且,Tim-3的表達(dá)水平與Ⅲ期NSCLC患者的無疾病生存期(disease free survival,DFS)也顯著相關(guān)(χ~2=6.135,P=0.013,中位DFS分別為41和24個(gè)月),高表達(dá)Tim-3的NSCLC患者DFS短。另外,在Ⅲ期NSCLC患者中,Tim-3在淋巴細(xì)胞中的表達(dá)水平與OS和PFS呈負(fù)相關(guān)(χ~2=4.737,P=0.030,中位OS分別為80和47個(gè)月;χ~2=5.882,P=0.015,中位DFS分別為41和24個(gè)月)。結(jié)論:Tim-3在腫瘤免疫中起負(fù)性調(diào)節(jié)作用從而促進(jìn)免疫逃逸,對(duì)患者的生存及預(yù)后有不良影響。
[Abstract]:Background & AIM: t cell immunoglobulin and mucin domain molecule 3T cell immunoglobulin and mucin-domaincontaining molecules 3 Tim-3 play an important role in immunomodulation and participate in the occurrence and development of many diseases. The purpose of this study was to investigate the expression and clinical significance of negative costimulatory molecule Tim-3 in infiltrated macrophages of non-small cell lung cancer in non-small cell lung cancer. The expression of Tim-3 in 126 patients with NSCLC was detected by tissue chemistry. To analyze the relationship between the expression level of Tim-3 and clinicopathological features in tumor infiltrating macrophages. The effect of Tim-3 expression level on the prognosis of NSCLC patients was further analyzed. Results the expression of Tim-3-3 was mainly distributed in the cytoplasm of macrophages and in the cell membrane of tumor infiltrating macrophages and the tumor size. Lymph node metastasis and TNM staging were significantly correlated with the expression levels of P0. 002, 0. 045 and 0. 022% Tim-3 in tumor infiltrating macrophages, which significantly affected the survival and prognosis of patients with NSCLC, and the higher the expression of TMT-3 in stage 鈪，

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