本文選題：乳腺腫瘤　切入點：磁共振成像　出處：《中國臨床醫(yī)學影像雜志》2017年05期 　論文類型：期刊論文

【摘要】：目的:探討不同分子亞型乳腺癌的MRI特征。材料與方法 :回顧性分析139例病人的術(shù)前乳腺MRI圖像,包括強化方式、腫塊樣病灶強化后形態(tài)、邊緣、內(nèi)部強化特征、時間-信號強度曲線(TIC)類型、伴隨征象。同時記錄免疫組化指標ER、PR、HER-2的受體表達情況及Ki-67水平,按照乳腺癌分子亞型分類,分成Luminal A型、Luminal B型、HER-2陽性型和三陰性乳腺癌(TNBC)。以χ~2檢驗比較各分子亞型間MRI表現(xiàn)的差異,采用交叉列聯(lián)表方法分析二者的相關(guān)性。結(jié)果:Luminal A型32例(23.0%),Luminal B型76例(54.7%),HER-2陽性型14例(10.1%),TNBC 17例(12.2%)。腫塊樣強化病變119例,非腫塊樣病變20例。腫塊樣強化病變中,病變的邊緣與分子亞型呈低度相關(guān)(C=0.360,P=0.008),內(nèi)部強化特征與分子亞型呈中度相關(guān)(C=0.442,P=0.001),TIC類型與分子亞型呈低度相關(guān)(C=0.318,P=0.019),而病灶的形態(tài)及伴隨征象與分子亞型無相關(guān)性(C=0.065,P=0.791)。結(jié)論:不同分子亞型乳腺癌的MRI變現(xiàn)各異,分子亞型與部分MRI征象之間存在一定的相關(guān)性,通過術(shù)前MRI檢查有助于初步判定預后及初步確定治療方案。
[Abstract]:Objective: to investigate the MRI features of breast cancer with different molecular subtypes. Materials and methods: the preoperative MRI images of 139 patients with breast cancer were retrospectively analyzed, including the enhancement mode, the features of enhancement, margin and internal enhancement of tumor-like lesions. The receptor expression and Ki-67 level of ERP / HER-2 were recorded and classified according to the molecular subtype of breast cancer. Luminal A Luminal B positive and triple negative breast cancer were divided into two groups. The difference of MRI expression among different molecular subtypes was compared by 蠂 ~ 2 test. Results there were 32 cases of luminal B with 23% Luminal A and 76 cases of Luminal B with HER-2 positive type 14 cases with HER-2 positive type and 17 cases with TNBC with 10.1% HER-2. There were 119 cases of tumor-like enhancement and 20 cases of non-tumor-like lesions. There was a low correlation between the edge of the lesion and the molecular subtype, and a moderate correlation between the internal enhancement characteristics and the molecular subtype. The type of TIC was low correlated with the molecular subtype, while the morphology and accompanying sign of the lesion were not correlated with the molecular subtype. Conclusion: there is no correlation between the morphology and concomitant signs of the lesion and the molecular subtype. Conclusion: there is a low correlation between the TIC type and the molecular subtype of the lesion, and there is no correlation between the morphology and concomitant signs of the lesion and the molecular subtype. Conclusion: there is no correlation between the morphology and concomitant signs of the lesion and the molecular subtype. Conclusion:. The MRI of different molecular subtypes of breast cancer is different. There is a certain correlation between molecular subtypes and some MRI signs. MRI examination before operation is helpful to determine the prognosis and the treatment plan.
【作者單位】： 吉林省腫瘤醫(yī)院放射科;
【基金】：吉林省科技廳自然科學基金項目(20140101170JC)
【分類號】：R445.2;R737.9

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