本文選題：嬰幼兒血管瘤　切入點(diǎn)：伊曲康唑口服液　出處：《中國(guó)皮膚性病學(xué)雜志》2017年01期 　論文類型：期刊論文

【摘要】：患兒女,3個(gè)月,出生后第10天右腹部發(fā)現(xiàn)4個(gè)針尖大小紅色丘疹,體積逐漸增加至6mm×4mm×1.6mm(彩超測(cè)定皮損體積),色鮮紅,皮膚鏡下可見(jiàn)線團(tuán)塊分布的血管網(wǎng)。予以馬來(lái)酸噻嗎洛爾滴眼液局部濕敷(2次/d,每次1小時(shí),每次約0.5m L),3個(gè)多月后瘤體仍擴(kuò)大融合并隆起,皮膚鏡下血管網(wǎng)簇集成團(tuán),邊緣可見(jiàn)向外延伸的血管分支,提示仍有擴(kuò)大趨勢(shì)。更改治療為伊曲康唑口服液內(nèi)服[5mg/(kg·d)],治療期間皮損顏色逐漸變暗,表面出現(xiàn)裂隙凹陷和皺紋,使之分成小葉狀,皮膚鏡下血管網(wǎng)變模糊,血管數(shù)量逐漸減少。治療68天后(口服總量約2300 mg)臨床及皮膚鏡可觀察到血管瘤有明顯消退跡象遂停藥隨訪。4月后血管瘤基本消退,殘留少許纖維脂肪組織印跡。服藥期間患兒肝腎功能在正常范圍內(nèi),未見(jiàn)不適。伊曲康唑口服液治療嬰幼兒血管瘤服藥方法簡(jiǎn)單方便,患兒及家屬依從性好,治療效果滿意。皮膚鏡在原位精準(zhǔn)觀察治療過(guò)程血管瘤變化情況中起重要作用。
[Abstract]:At the 10th day after birth, 4 needle size red papules were found in the right abdomen, and the volume gradually increased to 6 mm 脳 4 mm 脳 1.6 mm. Under the skin microscope, there was a vascular network with the distribution of the lumps. The local wet compress of tiamolol maleate eye drops was given twice a day, one hour at a time, each time about 0.5 mL, and after more than 3 months, the tumor was still enlarged and fused, and the vascular network was clustered into a cluster under the dermoscope. The outstretched branches of the blood vessels were visible on the edge, indicating that there was still a tendency to expand. After treatment with itraconazole oral liquid [5 mg / kg / d], the skin color gradually darkened, and the surface of the skin became sunken and wrinkled, so that it could be divided into lobules. After 68 days of treatment (total oral dose of about 2 300 mg), clinical and dermatoscopic observation showed that the hemangioma showed obvious signs of regression. After April, the hemangioma basically subsided. Some residual fibrous fat tissue imprinting. The liver and kidney function of the children were in normal range during taking medicine, no discomfort was found. Itraconazole oral liquid was simple and convenient to treat infantile hemangioma, and the compliance of the children and their families was good. Dermatoscopy plays an important role in observing the changes of hemangioma in situ.
【作者單位】： 四川大學(xué)華西醫(yī)院皮膚性病科;
【基金】：國(guó)家自然科學(xué)基金面上項(xiàng)目(81472539)
【分類號(hào)】：R732.2

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本文編號(hào)：1632738