本文選題：結(jié)腸癌　切入點(diǎn)：ATP檸檬酸裂解酶　出處：《東南大學(xué)學(xué)報(醫(yī)學(xué)版)》2017年06期 　論文類型：期刊論文

【摘要】：目的:探索ATP檸檬酸裂解酶(ACLY)在結(jié)腸癌組織中的表達(dá)情況及其臨床病理學(xué)意義,為結(jié)腸癌的診治提供新思路。方法:以50例結(jié)腸癌患者為研究對象,用免疫組織化學(xué)染色方法觀察結(jié)腸癌患者的癌組織及對應(yīng)的癌旁組織標(biāo)本中ACLY的表達(dá),并研究ACLY表達(dá)的臨床病理學(xué)意義。結(jié)果:在結(jié)腸癌組織中ACLY表達(dá)顯著高于對應(yīng)的癌旁組織(P=0);ACLY高表達(dá)與結(jié)腸癌的浸潤深度、淋巴結(jié)轉(zhuǎn)移及TNM分期顯著相關(guān)(P值分別為0、0.005及0.007);與年齡、性別、腫瘤大小、組織分化程度無相關(guān)性(P0.05)。結(jié)論:ACLY在結(jié)腸腺癌組織中高表達(dá),且與腫瘤轉(zhuǎn)移相關(guān);ACLY有望成為結(jié)腸癌診治的一個新靶點(diǎn)。
[Abstract]:Objective: to explore the expression and clinicopathological significance of ATP citric acid lyase in colon cancer tissues, and to provide a new idea for the diagnosis and treatment of colon cancer. Immunohistochemical staining was used to observe the expression of ACLY in cancer tissues and adjacent tissues of patients with colon cancer. The clinicopathological significance of ACLY expression was studied. Results: the expression of ACLY in colon cancer tissues was significantly higher than that in the corresponding paracancerous tissues and the depth of invasion of colon cancer. There was no correlation between lymph node metastasis and TNM staging (P = 0. 005 and 0. 007), which was not correlated with age, sex, tumor size and tissue differentiation. ACLY associated with tumor metastasis is expected to be a new target for the diagnosis and treatment of colon cancer.
【作者單位】： 東南大學(xué)醫(yī)學(xué)院;東南大學(xué)附屬中大醫(yī)院消化內(nèi)科;
【分類號】：R735.35
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本文編號：1618071