本文選題：結腸癌　切入點：ATP檸檬酸裂解酶　出處：《東南大學學報(醫(yī)學版)》2017年06期 　論文類型：期刊論文

【摘要】：目的:探索ATP檸檬酸裂解酶(ACLY)在結腸癌組織中的表達情況及其臨床病理學意義,為結腸癌的診治提供新思路。方法:以50例結腸癌患者為研究對象,用免疫組織化學染色方法觀察結腸癌患者的癌組織及對應的癌旁組織標本中ACLY的表達,并研究ACLY表達的臨床病理學意義。結果:在結腸癌組織中ACLY表達顯著高于對應的癌旁組織(P=0);ACLY高表達與結腸癌的浸潤深度、淋巴結轉移及TNM分期顯著相關(P值分別為0、0.005及0.007);與年齡、性別、腫瘤大小、組織分化程度無相關性(P0.05)。結論:ACLY在結腸腺癌組織中高表達,且與腫瘤轉移相關;ACLY有望成為結腸癌診治的一個新靶點。
[Abstract]:Objective: to explore the expression and clinicopathological significance of ATP citric acid lyase in colon cancer tissues, and to provide a new idea for the diagnosis and treatment of colon cancer. Immunohistochemical staining was used to observe the expression of ACLY in cancer tissues and adjacent tissues of patients with colon cancer. The clinicopathological significance of ACLY expression was studied. Results: the expression of ACLY in colon cancer tissues was significantly higher than that in the corresponding paracancerous tissues and the depth of invasion of colon cancer. There was no correlation between lymph node metastasis and TNM staging (P = 0. 005 and 0. 007), which was not correlated with age, sex, tumor size and tissue differentiation. ACLY associated with tumor metastasis is expected to be a new target for the diagnosis and treatment of colon cancer.
【作者單位】： 東南大學醫(yī)學院;東南大學附屬中大醫(yī)院消化內(nèi)科;
【分類號】：R735.35
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本文編號：1618071