本文選題：微管相關(guān)蛋白　切入點(diǎn)：胰腺神經(jīng)內(nèi)分泌腫瘤　出處：《中國(guó)腫瘤臨床》2017年11期 　論文類型：期刊論文

【摘要】：目的:探索微管相關(guān)蛋白2(microtubule-associated protein 2,MAP2)與微管相關(guān)蛋白1B(microtubule-associated protein 1B,MAP1B)在預(yù)測(cè)胰腺神經(jīng)內(nèi)分泌腫瘤(pancreatic neuroendocrine tumors,PNETs)患者預(yù)后中的意義。方法:收集1999年12月至2016年12月來(lái)自于北京協(xié)和醫(yī)院、中山大學(xué)附屬第一醫(yī)院、復(fù)旦大學(xué)上海癌癥中心和Cedars-Sinai醫(yī)學(xué)中心(洛杉磯)193例患者的193個(gè)原發(fā)腫瘤標(biāo)本。免疫組織化學(xué)染色法分別檢測(cè)193例、120例PNETs組織中MAP2、MAP1B的表達(dá),隨后分析蛋白表達(dá)與患者臨床病理特征及預(yù)后的關(guān)系。結(jié)果:MAP2和MAP1B在PNETs患者中的陽(yáng)性率分別為45.6%(88/193)和64.2%(77/120)。MAP2表達(dá)陽(yáng)性的患者的總生存好于陰性患者(P=0.012)。另外,MAP2陽(yáng)性Ⅱ、Ⅲ期患者的總生存也優(yōu)于陰性者(P=0.017)。然而,MAP1B的表達(dá)與腫瘤大小、轉(zhuǎn)移、腫瘤組織學(xué)分級(jí)、臨床分期、總生存、無(wú)病生存均無(wú)相關(guān)性(P0.05)。結(jié)論:MAP2為潛在的預(yù)測(cè)PNETs患者預(yù)后的指標(biāo)。
[Abstract]:Objective: to investigate the prognostic significance of microtubule-associated protein 2map2 and microtubule-associated protein 1Bmap1B in patients with pancreatic neuroendocrine tumors. Methods: from December 1999 to December 2016, the patients with pancreatic neuroendocrine tumors were collected from Peking Union Hospital. In the first affiliated Hospital of Sun Yat-sen University, Shanghai Cancer Center of Fudan University and Cedars-Sinai Medical Center, 193 primary tumor specimens were collected from 193 patients of Los Angeles. Immunohistochemical staining was used to detect the expression of MAP2MAP1B in 120 cases of PNETs. Then the relationship between protein expression and clinicopathological characteristics and prognosis was analyzed. Results the positive rates of MAP1B and MP-2 in PNETs patients were 45.6% 88 / 193 and 64.22a / 120% .MAP2 positive patients' overall survival was better than that of negative patients (P < 0.012). In addition, the positive rate of MAP2 in patients with PNETs was higher than that in patients with negative expression of MAP2, and the total survival rate of patients with positive expression of MAP2 was better than that of patients with negative expression of MAP2. However, there was no correlation between the expression of MAP1B and tumor size, metastasis, tumor histological grade, clinical stage, total survival and disease-free survival in stage 鈪，

本文編號(hào)：1615768