發(fā)布時間：2018-03-15 09:18

  本文選題：胰腺癌　切入點(diǎn)：數(shù)據(jù)挖掘　出處：《山東中醫(yī)藥大學(xué)》2016年博士論文　論文類型：學(xué)位論文

【摘要】：目的:探尋胰腺癌的古文獻(xiàn)命名歸屬,挖掘醫(yī)家治療胰腺癌的臨床用藥規(guī)律。方法:文獻(xiàn)研究以中國知網(wǎng)、《中華醫(yī)典》光盤等計算機(jī)檢索為主,輔以手工檢索,以“中醫(yī)解剖”、“伒”、“附脾之物”、“脾之副臟”、“散膏”、“甜肉”、“脾”、“總提”、“積聚”等為關(guān)鍵詞,對中醫(yī)學(xué)近千種古籍文獻(xiàn)和現(xiàn)代文獻(xiàn)進(jìn)行檢索,篩選與中醫(yī)解剖、胰腺實(shí)體、積聚密切相關(guān)的內(nèi)容,厘清中醫(yī)解剖學(xué)發(fā)展滯緩原因,研究胰腺實(shí)體,并納入廣義的積聚概念進(jìn)行胰腺癌的古文獻(xiàn)研究;用藥規(guī)律研究則基于數(shù)據(jù)挖掘技術(shù),收集1978年至今中國知網(wǎng)、萬方數(shù)據(jù)知識服務(wù)平臺等數(shù)據(jù)庫收錄的中醫(yī)治療胰腺癌的文獻(xiàn),搜集中醫(yī)處方,并建立現(xiàn)代醫(yī)家處方數(shù)據(jù)庫。導(dǎo)師處方則通過于山東中醫(yī)藥大學(xué)附屬醫(yī)院門診跟診予以收集,建立導(dǎo)師處方數(shù)據(jù)庫。運(yùn)用SPSS Statistics 17.0軟件對處方進(jìn)行頻數(shù)分析和聚類分析,運(yùn)用Clementine 12.0軟件的Apriori算法進(jìn)行關(guān)聯(lián)分析,挖掘現(xiàn)代醫(yī)家和導(dǎo)師治療胰腺癌的基本規(guī)律及藥物之間的配伍關(guān)系。結(jié)果:文獻(xiàn)研究發(fā)現(xiàn)胰腺的功能包含在中醫(yī)脾的功能之中,胰腺癌與廣義的積聚關(guān)系密切。臨床研究發(fā)現(xiàn),現(xiàn)代醫(yī)家治療胰腺癌的高頻藥物為茯苓、白術(shù)、白花蛇舌草、柴胡、黃芪、黨參、莪術(shù)、半支蓮、丹參和薏苡仁,補(bǔ)虛藥使用頻率最高,清熱藥、活血祛瘀藥次之,藥味以苦、甘、辛為主,藥性以平、溫、微寒、寒為主,藥物多歸脾、肝、胃和肺經(jīng),常用藥對有谷芽與麥芽、桃仁與紅花、茵陳與梔子、半夏與陳皮、菝葜與紅藤等,注重補(bǔ)虛藥的應(yīng)用和配伍。導(dǎo)師治療胰腺癌的高頻藥物為莪術(shù)、柴胡、郁金、白術(shù)、蚤休、延胡索、枳殼、半夏、白芍、陳皮、萊菔子、麥芽、白花蛇舌草、生甘草、木香、薏苡仁和厚樸�；钛铕鏊幨褂米顬閺V泛,理氣藥次之,藥味以苦、辛、甘為主,藥性以溫、微寒、平、寒為主,藥物亦多歸脾、肝、胃和肺經(jīng),常用藥對有半夏與陳皮、白英與蛇莓、生地與天花粉、白術(shù)與枳殼、葛根與羌活、檳榔與火麻仁等,尤為重視活血祛瘀藥的應(yīng)用與配伍。結(jié)論:1.胰腺的功能歸中醫(yī)脾所主。2.廣義的積聚可作為胰腺癌的古文獻(xiàn)命名歸屬。3.醫(yī)家治療胰腺癌的基本原則是一致的,注重補(bǔ)虛藥、活血祛瘀藥、理氣藥、清熱藥的應(yīng)用,并通過配伍增強(qiáng)療效。
[Abstract]:Objective: to explore the naming of ancient literature on pancreatic cancer and to find out the rule of clinical use of medicine for pancreatic cancer. Methods: the literature was mainly searched by computer such as the Chinese knowledge Network, the Chinese Medical Code and CD, and was supplemented by manual retrieval. With the key words of "anatomy of traditional Chinese medicine", "Li", "thing with spleen", "accessory viscera of spleen", "powder cream", "sweet meat", "spleen", "total extract", "accumulation", etc., nearly one thousand ancient books and modern literature of traditional Chinese medicine were searched for screening and screening with traditional Chinese medicine anatomy, pancreatic entity, etc. Accumulation of closely related content, clarify the reasons for the slow development of traditional Chinese medicine anatomy, study pancreatic entities, and incorporate a broad concept of accumulation to carry out the ancient literature study of pancreatic cancer, while the study of drug use law is based on data mining technology, Collect the literature on the treatment of pancreatic cancer in Chinese medicine collected from 1978 to now in databases such as China Zhiwang, Wanfang data and knowledge Service platform, and collect Chinese medicine prescriptions. In addition, the database of prescriptions of modern doctors was established, and the prescriptions of mentors were collected through out-patient consultation in the affiliated hospitals of Shandong University of traditional Chinese Medicine, and the database of prescriptions of tutors was established. The frequency analysis and cluster analysis of prescriptions were carried out by using SPSS Statistics 17.0 software. By using Apriori algorithm of Clementine 12.0 software, the association analysis was carried out to find out the basic law of modern doctors and mentors in the treatment of pancreatic cancer and the compatibility between drugs. Results: the function of pancreas was found to be included in the function of spleen in traditional Chinese medicine. Clinical studies have found that the high frequency drugs used by modern physicians for the treatment of pancreatic cancer are Poria cocos, Atractylodes macrocephala, Atractylodes nigra, Radix Bupleurum, Radix Astragali, Codonopsis, Curcuma, Radix Salviae Miltiorrhizae, Radix Salviae Miltiorrhizae and Coix seed. The medicine of tonifying deficiency is the most frequently used, the medicine of clearing away heat, activating blood circulation and removing blood stasis is the second, the medicine flavor is bitter, sweet, Xin mainly, the medicine is mainly flat, warm, slight cold, cold mainly, the medicine is mostly returned to spleen, liver, stomach and lung meridian, common medicine has grain germ and malt, peach kernel and safflower, Yinchen and Gardenia, Pinellia ternata and Pericarpium, Smilax china and red vine, etc., pay attention to the application and compatibility of tonifying drugs for pancreatic cancer. Semen Raphani, Malt, Sargassum, Glycyrrhiza uralensis, Radix Magnoliae, Coix seed and Magnolia officinalis. Drugs for activating Blood Circulation and removing Blood stasis are the most widely used, followed by drugs for regulating Qi, bitter, Xin, and Gan as the main drugs, the medicine is mainly warm, slightly cold, flat, cold, and the medicine is mostly returned to the spleen. Liver, stomach and Lung Meridians, commonly used for the treatment of Pinellia ternata and Chen Peel, White English and Snake berries, Raw Land and Trichosanthus, Atractylodes macrocephala and Fructus Aurantii, Pueraria and Notopterygium, Betelnut and Flamella seed, etc. Particular attention was paid to the application and compatibility of drugs for activating blood circulation and removing blood stasis. Conclusion 1.The function of pancreas belongs to the spleen of traditional Chinese medicine. 2.Generalized accumulation can be named as the ancient literature of pancreatic cancer .3.The basic principles of physicians in the treatment of pancreatic cancer are consistent and pay attention to tonifying deficiency medicine. Blood-activating drugs, qi-regulating drugs, heat-clearing drugs, and through compatibility to enhance the efficacy.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級別】：博士
【學(xué)位授予年份】：2016
【分類號】：R735.9

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